IL-3 受体的表达及其对人 T 和 B 细胞的影响。
Expression of IL-3 receptors and impact of IL-3 on human T and B cells.
机构信息
Department of Internal Medicine II - Nephrology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93042 Regensburg, Germany.
Department of Internal Medicine II - Nephrology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93042 Regensburg, Germany.
出版信息
Cell Immunol. 2018 Dec;334:49-60. doi: 10.1016/j.cellimm.2018.09.005. Epub 2018 Sep 26.
A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL-3 modulates the activation and survival of these cells. We show that the IL-3 receptor CD123 is substantially upregulated on proliferating CD4 and CD8 T as well as B cells. Upregulation of CD123 differs between various activators and can be further modulated by cytokines. Exposure of human T and B cells to IL-3 enhances proliferation and survival. IL-3 also induces a shift towards secretion of proinflammatory cytokines in T and B cells and reduces the expression of IL-10 in B cells. Thus IL-3 may have proinflammatory and immunostimulatory properties also in human autoimmune diseases.
大量的动物模型表明，IL-3 在 T 和 B 细胞介导的自身免疫性疾病的发展中起着重要作用。然而，人们对人类 T 和 B 细胞中 IL-3 受体的表达和调节以及 IL-3 如何调节这些细胞的激活和存活知之甚少。我们表明，增殖的 CD4 和 CD8 T 以及 B 细胞上显著上调了 IL-3 受体 CD123。CD123 的上调因各种激活剂而异，并可进一步受细胞因子调节。IL-3 暴露于人类 T 和 B 细胞可增强增殖和存活。IL-3 还可诱导 T 和 B 细胞中促炎细胞因子的分泌增加，并降低 B 细胞中 IL-10 的表达。因此，IL-3 可能在人类自身免疫性疾病中也具有促炎和免疫刺激特性。
Zotero 插件