de Freitas Marcelo Conrado, Ricci-Vitor Ana Laura, Freire Renan Valero, Caperuto Erico Chagas, Vanderlei Luiz Carlos Marques, Lira Fábio Santos, Rossi Fabrício Eduardo
Skeletal Muscle Assessment Laboratory (LABSIM), São Paulo State University (UNESP), School of Technology and Sciences, Department of Physical Education, Presidente Prudente, Brazil.
Department of Nutrition, São Paulo Western University-UNOESTE, Presidente Prudente, Brazil.
J Exerc Rehabil. 2018 Aug 24;14(4):671-679. doi: 10.12965/jer.1836256.128. eCollection 2018 Aug.
The aim of this study was to verify the autonomic modulation and blood pressure after adenosine-5'-triphosphate (ATP) supplementation associated to acute aerobic exercise in hypertensive women. Eleven hypertensive women (age, 61.8±5.0 years) completed a randomized, double blind trial: ATP supplement condition (ATP=400 mg) or placebo. After 30 min of supplementation or placebo intake, the subjects performed 30 min of aerobic exercise (70%-75% of maximum heart rate). The autonomic modulation was assessed by heart rate variability during rest and recovery (postexercise until 30 min of recovery), the square root of the mean squared difference between adjacent RR intervals (RMSSD), standard deviation of successive values (SDNN), low frequency (LF) and high frequency (HF) were measured. The blood pressure (systolic blood pressure [SBP] and diastolic blood pressure, mmHg) were recorded at rest, immediately postexercise, post-10, post-20, and post-30 min after exercise. For RMSSD, there was statistically significant difference during recovery, with higher RMSSD for ATP compared to placebo (rest=16.4±8.5 vs. placebo=11.6±4.0; ATP=18.5±9.7 msec; =0.020). When analyzing the delta (recovery minus rest), the RMSSD (ATP=2.1± 7.2 msec vs. placebo=-4.7±7.5 msec; =0.009), LF (ATP=-19.8±122.7 vs. placebo=-94.1±200.2 msec2; =0.02), and SDNN (ATP=-2.8±12.2 msec vs. placebo=-10.6±10.5 msec; =0.010) were higher for ATP than placebo. Furthermore, there was a greater postexercise hypotension at 20 min for ATP (SBP: ATP=-13.2±8.4 mmHg vs. placebo=-6.1±9.9 mmHg; =0.006). Acute ATP supplementation promoted greater postexercise hypotension for systolic blood pressure and induced faster recovery of heart rate variability in hypertensive women.
本研究的目的是验证高血压女性在补充5'-三磷酸腺苷（ATP）并进行急性有氧运动后自主神经调节和血压的变化情况。11名高血压女性（年龄61.8±5.0岁）完成了一项随机双盲试验：ATP补充组（ATP = 400毫克）或安慰剂组。在补充ATP或安慰剂30分钟后，受试者进行30分钟的有氧运动（最大心率的70%-75%）。通过静息和恢复期间（运动后至恢复30分钟）的心率变异性评估自主神经调节，测量相邻RR间期的均方根差（RMSSD）、连续值标准差（SDNN）、低频（LF）和高频（HF）。在静息、运动后即刻、运动后10分钟、20分钟和30分钟记录血压（收缩压[SBP]和舒张压，mmHg）。对于RMSSD，恢复期间有统计学显著差异，ATP组的RMSSD高于安慰剂组（静息时：ATP = 16.4±8.5，安慰剂 = 11.6±4.0；ATP = 18.5±9.7毫秒；P = 0.020）。分析差值（恢复值减去静息值）时，ATP组的RMSSD（ATP = 2.1±7.2毫秒，安慰剂 = -4.7±7.5毫秒；P = 0.009）、LF（ATP = -19.8±122.7，安慰剂 = -94.1±200.2毫秒²；P = 0.02）和SDNN（ATP = -2.8±12.2毫秒，安慰剂 = -10.6±10.5毫秒；P = 0.010）均高于安慰剂组。此外，ATP组在运动后20分钟时的运动后低血压更明显（SBP：ATP = -13.2±8.4 mmHg，安慰剂 = -6.1±9.9 mmHg；P = 0.006）。急性补充ATP可使高血压女性的收缩压运动后低血压更明显，并使心率变异性恢复更快。
