Institute of Pathology, Medical Experimental Centre, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Department of Nephrology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Biomed Res Int. 2018 Sep 12;2018:1462802. doi: 10.1155/2018/1462802. eCollection 2018.
Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney injury, which involves both local events in the kidney and interconnected and interdependent systemic effects in the body, cisplatin rodent model is indispensable in the investigation of underlying mechanisms and potential treatment strategies of both acute and chronic kidney injury. Cisplatin rodent model is well appreciated and widely used model due to its simplicity. It has many similarities to human cisplatin nephrotoxicity, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using cisplatin model. The present paper is aimed at giving a concise insight into the complex characteristics of cisplatin rodent model and heterogeneity of cisplatin dosage regimens as well as outlining factors that can severely influence the outcome of the model and the study. Challenges for future research are also mentioned.
顺铂是一种用于治疗多种恶性肿瘤的抗肿瘤药物。然而，其主要的剂量限制副作用是肾损伤，这是一个主要的临床关注点。为了帮助理解肾损伤发展过程中的机制，已经开发了顺铂啮齿动物模型。鉴于肾损伤的复杂发病机制，其中涉及肾脏中的局部事件以及体内相互关联和相互依存的全身效应，顺铂啮齿动物模型对于研究急性和慢性肾损伤的潜在机制和治疗策略是不可或缺的。由于其简单性，顺铂啮齿动物模型是一种备受赞赏且广泛使用的模型。它与文中提到的人类顺铂肾毒性有许多相似之处。尽管它简单且适用性广泛，但在使用顺铂模型时也需要考虑一些陷阱。本文旨在简要介绍顺铂啮齿动物模型的复杂特征以及顺铂剂量方案的异质性，并概述可能严重影响模型和研究结果的因素。还提到了未来研究的挑战。
