Dr. T. Elschner, Prof. T. Heinze, Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstraße 10,, 07743, Jena, Germany.
F. Obst, Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6,, 01069, Dresden, Germany.
Macromol Biosci. 2018 Nov;18(11):e1800258. doi: 10.1002/mabi.201800258. Epub 2018 Oct 1.
In context with facile and efficient syntheses of functional polymeric materials, the combination of polysaccharides and functional moieties based on renewable resources is a sustainable and valuable approach. This review presents alternatives to prominent click reactions utilizing biopolymer derivatives with furfuryl and maleimide groups. On the one hand, the cross-linking by Diels-Alder reaction of these polymers enables the synthesis of novel materials in the fields of self-healing polymers, tissue engineering, and drug delivery. On the other hand, thiol-ene click reactions allow their conjugation to complex (bio)molecules. Different synthetic strategies are reviewed and the applicability of functional materials is evaluated.
在简便高效地合成功能高分子材料的背景下，将多糖与基于可再生资源的功能基团相结合是一种可持续且有价值的方法。本综述介绍了利用具有糠基和马来酰亚胺基团的生物聚合物衍生物替代一些重要的点击反应。一方面，通过这些聚合物的 Diels-Alder 反应交联，可以在自修复聚合物、组织工程和药物输送等领域合成新型材料。另一方面，巯基-烯点击反应可以使它们与复杂的（生物）分子结合。综述了不同的合成策略，并评估了功能材料的适用性。
