State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China.
Elionnature Biological Technology Co., Ltd., Nanjing 210038, China.
Curr Med Chem. 2020;27(12):1997-2011. doi: 10.2174/0929867325666181001104550.
Plants have always been an important source of medicines for humans, and licorice is a very significant herb in the development of humans. As a traditional herb, it is widely cultivated in China, Japan, Russia, Spain and India. With the development of organic chemistry and biochemistry, various chemical ingredients extracted from licorice have been studied and identified. Among them, many chemical components were considered to have strong pharmacological activities, such as anti-inflammatory, anti-ulcer, antibacterial, anticancer and so on. Based on those reports, licorice has attracted the attention of many researchers in recent years, and they are devoted to discovering the active ingredients and mechanism of action of active compounds. Licorice flavonoids are one of the main extracts of licorice root and stem and have many potential biological properties. This paper aims to summarize the four kinds of licorice flavonoids, including liquiritigenin, isoliquiritigenin, licochalcone (including licochalcone A and licochalcone B) and glabridin, about their biological activities of anti-inflammatory, anticancer, antibacterial.
植物一直是人类药物的重要来源，而甘草是人类发展过程中非常重要的草药。作为一种传统草药，它在中国、日本、俄罗斯、西班牙和印度广泛种植。随着有机化学和生物化学的发展，从甘草中提取的各种化学成分已被研究和鉴定。其中，许多化学成分被认为具有很强的药理活性，如抗炎、抗溃疡、抗菌、抗癌等。基于这些报道，甘草近年来引起了许多研究人员的关注，他们致力于发现活性成分和活性化合物的作用机制。甘草类黄酮是甘草根和茎的主要提取物之一，具有许多潜在的生物学特性。本文旨在综述四种甘草类黄酮，包括甘草素、异甘草素、甘草查尔酮（包括甘草查尔酮 A 和甘草查尔酮 B）和甘草素，关于它们的抗炎、抗癌、抗菌的生物活性。
