恒河猴宫颈阴道微生物群分析采样方法的比较
Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques.
作者信息
Schmidt Brian A, Phillips Ronald, Rolston Matthew, Raeman Reben, Iyer Smita S
机构信息
Center for Comparative Medicine, University of California, Davis, California.
Host Microbe Systems Biology Core, University of California, Davis, California.
出版信息
J Med Primatol. 2019 Feb;48(1):54-57. doi: 10.1111/jmp.12381. Epub 2018 Oct 2.
Abstract
Cervicovaginal bacteria cause inflammation which in turn increases HIV risk. Profiling the cervicovaginal microbiome, therefore, is instrumental for vaccine development. We show that the microbiome profile captured by cervicovaginal lavage is comparable to samples obtained by vaginal swabs. Thus, lavage may serve as a sampling strategy in NHP vaccine studies.
摘要
宫颈阴道细菌会引发炎症，进而增加感染艾滋病毒的风险。因此，分析宫颈阴道微生物群对于疫苗研发至关重要。我们发现，通过宫颈阴道灌洗获取的微生物群谱与通过阴道拭子获取的样本相当。因此，灌洗可作为非人灵长类动物疫苗研究中的一种采样策略。
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