基于平面手性二茂铁的 N-杂环卡宾配体。
Planar-Chiral Ferrocene-Based N-Heterocyclic Carbene Ligands.
机构信息
Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.
Molecular Chirality Research Center, Chiba University, Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.
出版信息
Chemistry. 2018 Dec 12;24(70):18575-18586. doi: 10.1002/chem.201803903. Epub 2018 Nov 28.
In the last few decades, N-heterocyclic carbene (NHC) ligands, characterized by attractive features, have increased their presence in transition-metal catalysis. However, chiral NHC ligands still require further design enhancement to realize far more exciting synthetic applications. This review documents advances in chiral NHC ligands, focusing on planar-chiral ferrocene-based NHCs. As the basic shape of most classes of NHC rings is planar, it seems rational to employ a planar-chiral element in the design of chiral NHC ligands.
在过去几十年中，具有吸引力特征的 N-杂环卡宾（NHC）配体在过渡金属催化中得到了越来越多的应用。然而，手性 NHC 配体仍需要进一步的设计改进，以实现更令人兴奋的合成应用。本综述记录了手性 NHC 配体的进展，重点介绍了基于平面手性二茂铁的 NHC。由于大多数 NHC 环的基本形状为平面，因此在手性 NHC 配体的设计中采用平面手性元素似乎是合理的。
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