通过铜催化的α-胺化和氧化C-C键裂解，由酮类化合物新颖合成多官能团芳基咪唑。
Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C-C bond cleavage.
作者信息
Huang Jiangkun, Luo Lan, Xing Naiguo, Gu Linghui, Li Chen, Han Qiao, Zheng Shilong, He Ling
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University Chengdu Sichuan 610041 P. R. China
Department of Chemistry and RCMI Cancer Research Center, Xavier University of Louisiana New Orleans LA 70125 USA.
出版信息
RSC Adv. 2020 Apr 6;10(23):13815-13819. doi: 10.1039/d0ra01408g. eCollection 2020 Apr 1.
A one-pot synthesis, initiated by a copper salt with inorganic (NH)CO as the nitrogen source, forms divergent aryl imidazole derivatives from ketones α-amination and oxidative C-C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility.
以铜盐引发、无机（NH）₂CO作为氮源的一锅法合成，通过酮的α-胺化和氧化C-C键裂解反应生成多种芳基咪唑衍生物。该方法为咪唑衍生物提供了一种简单快速的合成方法，且具有一定的通用性。
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