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血管活性肠肽（VIP）的碘化衍生物是猫胰腺和大鼠颌下唾液腺的激动剂。

Iodinated derivatives of the vasoactive intestinal polypeptide (VIP) are agonists at the cat pancreas and the rat submandibular salivary gland.

作者信息

Halldén G, Abens J, Engström C, Westlind A, Mutt V, Bartfai T

出版信息

Regul Pept. 1986 Dec 22;16(2):183-8. doi: 10.1016/0167-0115(86)90061-3.

DOI:10.1016/0167-0115(86)90061-3
PMID:3027765
Abstract

Porcine VIP was iodinated by the chloramine-T method. The reaction products, which were separated by high pressure liquid chromatography, included residual native VIP, oxidized VIP and at least two iodinated VIP species. The iodo-VIP derivatives were recognized by antibodies raised against VIP and by VIP receptors. Furthermore, they appear to be approximately equipotent agonists to VIP in activating the adenylate cyclase in membranes from the rat submandibular salivary gland and in the stimulation of pancreatic secretion in vivo.

摘要

猪血管活性肠肽（VIP）采用氯胺-T法进行碘化。通过高压液相色谱分离得到的反应产物包括残留的天然VIP、氧化的VIP以及至少两种碘化VIP物种。碘化VIP衍生物可被针对VIP产生的抗体以及VIP受体识别。此外，在激活大鼠下颌下唾液腺膜中的腺苷酸环化酶以及体内刺激胰腺分泌方面，它们似乎是与VIP效力大致相当的激动剂。

相似文献

1
Iodinated derivatives of the vasoactive intestinal polypeptide (VIP) are agonists at the cat pancreas and the rat submandibular salivary gland.血管活性肠肽（VIP）的碘化衍生物是猫胰腺和大鼠颌下唾液腺的激动剂。
Regul Pept. 1986 Dec 22;16(2):183-8. doi: 10.1016/0167-0115(86)90061-3.
2
Effector mechanisms of peptides of the VIP family.血管活性肠肽家族肽的效应机制。
Peptides. 1986;7 Suppl 1:101-7. doi: 10.1016/0196-9781(86)90171-3.
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Pharmacological, molecular and functional characterization of vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide receptors in the rat pineal gland.大鼠松果体中血管活性肠肽/垂体腺苷酸环化酶激活肽受体的药理学、分子及功能特性
Neuroscience. 1998 Aug;85(3):887-96. doi: 10.1016/s0306-4522(97)00668-4.
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Interaction of vasoactive intestinal peptide (VIP) and N-terminally modified VIP analogs with rat pancreatic, hepatic and pituitary membranes.血管活性肠肽（VIP）及N端修饰的VIP类似物与大鼠胰腺、肝脏和垂体膜的相互作用。
Eur J Biochem. 1986 Aug 15;159(1):45-9. doi: 10.1111/j.1432-1033.1986.tb09831.x.
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Characterization of binding sites for VIP-related peptides and activation of adenylate cyclase in developing pancreas.发育中胰腺中血管活性肠肽相关肽结合位点的表征及腺苷酸环化酶的激活
Am J Physiol. 1991 Feb;260(2 Pt 1):G265-74. doi: 10.1152/ajpgi.1991.260.2.G265.
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[mono[125I]iodo-Tyr10,MetO17]-vasoactive intestinal polypeptide. Preparation, characterization, and use for radioimmunoassay and receptor binding.[单[¹²⁵I]碘代-Tyr¹⁰,甲硫氨酸亚砜¹⁷]-血管活性肠肽。制备、表征及其在放射免疫分析和受体结合中的应用。
J Biol Chem. 1986 Apr 25;261(12):5320-7.
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Vasoactive intestinal peptide receptor antagonists in rat seminal vesicle membranes.大鼠精囊膜中的血管活性肠肽受体拮抗剂
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[D-Phe4]peptide histidine-isoleucinamide ([D-Phe4]PHI), a highly selective vasoactive-intestinal-peptide (VIP) agonist, discriminates VIP-preferring from secretin-preferring receptors in rat pancreatic membranes.[D-苯丙氨酸4]肽组氨酸异亮氨酰胺（[D-苯丙氨酸4]PHI），一种高度选择性的血管活性肠肽（VIP）激动剂，可区分大鼠胰腺膜中偏好VIP的受体和偏好促胰液素的受体。
Eur J Biochem. 1987 Jun 1;165(2):243-9. doi: 10.1111/j.1432-1033.1987.tb11434.x.
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Effect of freezing on the coupling of VIP receptors to adenylate cyclase in rat liver membranes.
Life Sci. 1988;42(5):505-10. doi: 10.1016/0024-3205(88)90090-2.
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Vasoactive intestinal peptide receptors in pancreas and liver. Structure-function relationship.
Ann N Y Acad Sci. 1988;527:238-56. doi: 10.1111/j.1749-6632.1988.tb26984.x.

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