Moro Hiroshi, Koshio Nao, Bamba Yuuki, Koizumi Takeshi, Cho Hiromi, Aoki Nobumasa, Hayashi Masachika, Tsubata Chikako, Sakagami Akiko, Sato Mizuho, Sakagami Takuro, Koya Toshiyuki, Tanabe Yoshinari, Kikuchi Toshiaki
Kansenshogaku Zasshi. 2017 Jan;91(1):1-6.
Serum (1→3) beta-D-glucan (BG) measurement is a useful test for systemic mycoses, and often used. On the other hand, various factors, including administration of intravenous immunoglobulins (IVIG) may cause false-positives. In the present study, we measured BG concentration of seven IVIG preparations with three lots respectively. BG levels varied with individual IVIG preparations (<3.0 - >300 pg/mL), and contamination from manufacturing processes was suspected. With serum BG concentration of clinical specimens obtained in Niigata University Medical & Dental Hospital, the difference between before and after administration of IVIG were calculated. The false-positive rate of BG due to IVIG administration was 9.8 %, and the positive predective value was reduced to 37.5%. Above all, administration of IVIG can complicate the BG test's interpretation, and caution is required.
血清（1→3）β-D-葡聚糖（BG）检测是一种用于系统性真菌病的有用检测方法，且经常被使用。另一方面，包括静脉注射免疫球蛋白（IVIG）在内的各种因素可能导致假阳性。在本研究中，我们分别测量了七个批次的三种IVIG制剂的BG浓度。BG水平因不同的IVIG制剂而有所不同（<3.0->300 pg/mL），怀疑存在生产过程中的污染。利用新潟大学医学和牙科学院获得的临床标本的血清BG浓度，计算了IVIG给药前后的差异。IVIG给药导致BG的假阳性率为9.8%，阳性预测值降至37.5%。最重要的是，IVIG给药会使BG检测结果的解读变得复杂，需要谨慎对待。
