No information is available on the use of eravacycline during breastfeeding. The manufacturer states that breastfeeding is not recommended during treatment and for 4 days after the last dose. However, available literature indicates that there is not likely to be harm in short-term use of eravacycline during lactation because the drug is 79 to 90% bound to plasma proteins, so milk levels are likely low and absorption by the infant is likely inhibited by the calcium in breastmilk. Although the manufacturer recommends avoiding breastfeeding during administration of eravacycline and for 4 days after the last dose, short-term use of eravacycline is probably acceptable in nursing mothers. If an infant is breastfed, monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (e.g., thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis. As a theoretical precaution, avoid prolonged or repeat courses during nursing.
关于在母乳喂养期间使用依拉环素的信息尚无可用资料。制造商声明，治疗期间及最后一剂后4天不建议母乳喂养。然而，现有文献表明，哺乳期短期使用依拉环素不太可能有害，因为该药物与血浆蛋白的结合率为79%至90%，所以乳汁中的药物水平可能较低，且母乳中的钙可能会抑制婴儿对药物的吸收。尽管制造商建议在使用依拉环素期间及最后一剂后4天避免母乳喂养，但哺乳期母亲短期使用依拉环素可能是可以接受的。如果婴儿进行母乳喂养，需监测婴儿是否有胃肠道菌群受影响的可能，如腹泻、念珠菌病（如鹅口疮、尿布疹），或罕见的大便带血，提示可能有抗生素相关性结肠炎。作为理论上的预防措施，哺乳期应避免长期或重复用药疗程。
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