No information is available on the use of omadacycline during breastfeeding. It is unknown how much omadacycline is excreted into breastmilk, but the drug is only about 35% absorbed orally under optimal circumstances, and is probably less from milk because of its calcium content. Although the manufacturer recommends avoiding breastfeeding during administration of omadacycline and for 4 days after the last dose, short-term use of omadacycline is probably acceptable in nursing mothers. If an infant is breastfed, monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (e.g., thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis. As a theoretical precaution, avoid prolonged or repeat courses during nursing.
关于奥玛环素在母乳喂养期间的使用尚无可用信息。目前尚不清楚有多少奥玛环素会排泄到母乳中，但在最佳情况下，该药物口服吸收率仅约35%，由于其钙含量，从乳汁中的吸收率可能更低。尽管制造商建议在使用奥玛环素期间及最后一剂后4天内避免母乳喂养，但哺乳期母亲短期使用奥玛环素可能是可以接受的。如果婴儿接受母乳喂养，需监测婴儿是否有胃肠道菌群受影响的可能，如腹泻、念珠菌病（如鹅口疮、尿布疹），或罕见的粪便带血提示可能存在抗生素相关性结肠炎。作为理论上的预防措施，在哺乳期间避免长期或重复用药疗程。
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