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一名年轻患者因使用含辛弗林的健身补充剂发生升主动脉夹层。

Ascending aortic dissection in a young patient using a synephrine-containing workout supplement.

作者信息

Doctorian Tanya, Do Bao

机构信息

Department of Internal Medicine, Kaiser Permanente Fontana Medical Center, Fontana, CA, USA.

Department of Cardiology, Kaiser Permanente Fontana Medical Center, Fontana, CA, USA.

出版信息

J Cardiol Cases. 2017 Mar 6;15(5):150-152. doi: 10.1016/j.jccase.2016.12.008. eCollection 2017 May.

DOI:10.1016/j.jccase.2016.12.008
PMID:30279764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6149182/
Abstract

Aortic dissection in young patients presents a clinical and diagnostic challenge. Atypical symptoms of ascending aortic dissection can delay presentation and diagnosis. Here, we describe a patient with delayed diagnosis of an atypical presentation of ascending aortic dissection after using a synephrine-containing pre-workout supplement. The diagnosis was initially missed on computed tomography, but subsequently made on echocardiography. This is the first reported case of ascending aortic dissection in the setting of synephrine supplementation. This case illustrates a potential cardiovascular adverse effect of synephrine and highlights the need for clinical trials without conflicts of interest assessing its safety. < The aims of this report are to highlight the diagnostic challenge of an atypical presentation of ascending aortic dissection and to illustrate a potential cardiovascular adverse effect of synephrine supplementation.>.

摘要

年轻患者的主动脉夹层带来了临床和诊断方面的挑战。升主动脉夹层的非典型症状会延迟就诊和诊断。在此,我们描述了一名患者,其在使用含辛弗林的运动前补充剂后,升主动脉夹层非典型表现的诊断被延迟。计算机断层扫描最初漏诊,但随后经超声心动图确诊。这是首次报道的在补充辛弗林情况下发生升主动脉夹层的病例。该病例说明了辛弗林潜在的心血管不良反应,并强调了开展无利益冲突的安全性评估临床试验的必要性。<本报告的目的是突出升主动脉夹层非典型表现的诊断挑战,并说明补充辛弗林潜在的心血管不良反应。>

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Tex Heart Inst J. 2009;36(6):586-90.
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Possible association of acute lateral-wall myocardial infarction and bitter orange supplement.急性侧壁心肌梗死与苦橙补充剂之间可能存在的关联。
Ann Pharmacother. 2004 May;38(5):812-6. doi: 10.1345/aph.1D473. Epub 2004 Mar 16.
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J Am Coll Cardiol. 2004 Feb 18;43(4):665-9. doi: 10.1016/j.jacc.2003.08.054.
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