The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.
Chem Commun (Camb). 2018 Nov 20;54(93):13072-13075. doi: 10.1039/c8cc06757k.
A new DNA binding small molecule, NCD-CC is reported. NCD-CC has a NCD domain, which recognizes the G-G mismatch in a CGG/CGG triad, and a cysteinylcystein (CC) moiety. Dimerization of NCD-CC through intermolecular disulfide bond formation was accelerated in the presence of CGG repeat DNA.
报道了一种新的 DNA 结合小分子 NCD-CC。NCD-CC 具有一个 NCD 结构域，该结构域识别 CGG/CGG 三核苷酸中的 G-G 错配，并具有半胱氨酸-半胱氨酸（CC）部分。在 CGG 重复 DNA 的存在下，通过分子间二硫键形成促进了 NCD-CC 的二聚化。
