Hangzhou Dianzi University, Zhejiang, 310018, China.
Department of Clinical Laboratory, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, 310002, China.
Anal Bioanal Chem. 2019 Jan;411(1):21-36. doi: 10.1007/s00216-018-1361-7. Epub 2018 Oct 2.
A blood glucose meter is an electronic medical device used for determining the concentration of glucose in blood. These meters have undergone five phases of development: washed blood glucose meters, wiped blood glucose meters, colorimetric blood glucose meters, electrochemical blood glucose meters, and micro, multiple site blood glucose meters. Thanks to their speed, portability, low cost, and easy operation, blood glucose meters have been widely available for use in clinical diagnosis. Recently, coupling of target recognition elements (antibody-antigen recognition, nucleic acid hybridization, enzyme recognition, and click chemistry) with signal transduction and amplification strategies (glucose-generating enzymes, nicotinamide adenine dinucleotide (NADH)-generating enzymes, encapsulated glucose, nanomaterials, and cyclic amplification of DNA) has allowed various targets to be determined via the relationship between the signal of the blood glucose meter and the concentration of targets. In this paper, a brief review of the development and mechanism of blood glucose meters is given first. Then, more details on the application of blood glucose meters in analysis are described, including biomedical analysis, food analysis, and environmental analysis. Finally, the prospect of future development of blood glucose meters is also discussed. Graphical abstract ᅟ.
血糖仪是一种用于测定血液中葡萄糖浓度的电子医疗设备。这些血糖仪经历了五代发展：湿式血糖仪、抹血血糖仪、比色血糖仪、电化学血糖仪和微量、多点血糖仪。由于其速度快、便携、成本低、操作简单，血糖仪已广泛应用于临床诊断。最近，通过将目标识别元件（抗体-抗原识别、核酸杂交、酶识别和点击化学）与信号转导和放大策略（葡萄糖生成酶、烟酰胺腺嘌呤二核苷酸（NADH）生成酶、包封葡萄糖、纳米材料和 DNA 的循环扩增）相结合，使得可以通过血糖仪的信号与目标浓度之间的关系来确定各种目标。本文首先简要综述了血糖仪的发展和工作机制。然后，更详细地描述了血糖仪在分析中的应用，包括生物医学分析、食品分析和环境分析。最后，还讨论了血糖仪未来的发展前景。
