Rubin D A, Duran A T, Haqq A M, Gertz E R, Dumont-Driscoll M
Department of Kinesiology, California State University, Fullerton, CA, USA.
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Pediatr Obes. 2018 Nov;13(11):734-743. doi: 10.1111/ijpo.12462. Epub 2018 Sep 17.
Physical activity is associated with improved cardiometabolic markers in children with nonsyndromic obesity (NSO). Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder characterized by obesity.
To compare cardiometabolic changes in response to a home-based parent-facilitated physical activity intervention between children with PWS or with NSO.
Participants included 18 children with PWS (age = 10.5 ± 0.7y; body fat = 44.6 ± 2.0%) and 30 children with NSO (age = 9.7 ± 0.2y; body fat = 44.8 ± 1.2%). Active Play @ Home was a 24-week physical activity intervention curriculum containing playground-based and active video games completed 4 days per week. Pre- and post-intervention measurements included physical activity, body composition, blood samples analysed for glucose, insulin, lipids and cytokines, and insulin resistance computed using the homeostatic model of assessment for insulin resistance (HOMA-IR).
All children (n = 48) showed a significant decrease in Interleukin-8 (3.64 ± 0.24 vs. 3.06 ± 0.22 pg/mL). Children with obesity who did not gain or who lost body fat percentage (n = 18) demonstrated a significant decrease in HOMA-IR (3.17 ± 0.39 vs. 2.72 ± 0.34) and an increase in high-density lipoprotein (44.30 ± 2.51 vs. 47.29 ± 2.59 mg/dL). All other measurements showed no significant changes.
The most favourable changes in cardiometabolic factors were observed in children with nonsyndromic obesity who demonstrated no gain or a decrease in body fat percentage.
体育活动与非综合征性肥胖（NSO）儿童心脏代谢指标的改善有关。普拉德-威利综合征（PWS）是一种以肥胖为特征的神经发育障碍。
比较PWS患儿和NSO患儿在家庭家长辅助体育活动干预后的心脏代谢变化。
参与者包括18名PWS患儿（年龄=10.5±0.7岁；体脂=44.6±2.0%）和30名NSO患儿（年龄=9.7±0.2岁；体脂=44.8±1.2%）。“在家积极玩耍”是一项为期24周的体育活动干预课程，包括基于操场的活动和电子游戏，每周进行4天。干预前后的测量指标包括体育活动、身体成分、检测血糖、胰岛素、血脂和细胞因子的血样，以及使用胰岛素抵抗稳态模型（HOMA-IR）计算的胰岛素抵抗。
所有儿童（n=48）的白细胞介素-8均显著降低（3.64±0.24 vs. 3.06±0.22 pg/mL）。未增加或体脂百分比下降的肥胖儿童（n=18）的HOMA-IR显著降低（3.17±0.39 vs. 2.72±0.34），高密度脂蛋白增加（44.30±2.51 vs. 47.29±2.5 mg/dL）。所有其他测量指标均无显著变化。
在非综合征性肥胖且体脂百分比未增加或下降的儿童中，观察到心脏代谢因素最有利的变化。
