Department of Experimental Psychology, Universidad de Sevilla, Seville, Spain.
PLoS One. 2018 Oct 3;13(10):e0200178. doi: 10.1371/journal.pone.0200178. eCollection 2018.
Dopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol can act as an unconditioned stimulus, we carried out two experiments in which the administration of haloperidol was repeatedly paired with the presence of distinctive contextual cues that served as a Conditioned Stimulus. Paradoxically, the results revealed a dose-dependent increase in locomotor activity following conditioning with dopamine antagonist (Experiments 1) that was susceptible of extinction when the conditioned stimulus was presented repeatedly by itself after conditioning (Experiment 2). These data are interpreted from an associative perspective, considering them as a result of a classical conditioning process.
多巴胺拮抗剂药物对运动活动有深远的影响。特别是，D2 拮抗剂氟哌啶醇的给药会产生类似于僵住的状态。为了确认氟哌啶醇产生的多巴胺能活动的调节是否可以作为无条件刺激，我们进行了两项实验，其中氟哌啶醇的给药反复与独特的上下文线索配对，作为条件刺激。矛盾的是，结果显示，在使用多巴胺拮抗剂进行条件作用后，运动活动呈剂量依赖性增加（实验 1），而当条件刺激在条件作用后单独反复呈现时，这种增加很容易消失（实验 2）。这些数据从联想的角度进行解释，将其视为经典条件作用过程的结果。
