D2自身受体在调节多巴胺能神经元活动及传递中的作用。
The role of D2-autoreceptors in regulating dopamine neuron activity and transmission.
作者信息
Ford C P
机构信息
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106-4970, United States; Department of Neurosciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106-4970, United States.
出版信息
Neuroscience. 2014 Dec 12;282:13-22. doi: 10.1016/j.neuroscience.2014.01.025. Epub 2014 Jan 23.
Abstract
Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons and control the synthesis, release and uptake of dopamine. These Gi/o-coupled inhibitory receptors play a major part in shaping dopamine transmission. Found at both somatodendritic and axonal sites, autoreceptors regulate the firing patterns of dopamine neurons and control the timing and amount of dopamine released from their terminals in target regions. Alterations in the expression and activity of autoreceptors are thought to contribute to Parkinson's disease as well as schizophrenia, drug addiction and attention-deficit hyperactivity disorder (ADHD), which emphasizes the importance of D2-autoreceptors in regulating the dopamine system. This review will summarize the cellular actions of dopamine autoreceptors and discuss recent advances that have furthered our understanding of the mechanisms by which D2-receptors control dopamine transmission.
摘要
多巴胺D2自身受体在调节多巴胺能神经元的活动以及控制多巴胺的合成、释放和摄取方面发挥着关键作用。这些与Gi/o偶联的抑制性受体在塑造多巴胺传递过程中起主要作用。自身受体存在于树突体和轴突部位，调节多巴胺能神经元的放电模式，并控制多巴胺从其在靶区域的终末释放的时间和量。自身受体表达和活性的改变被认为与帕金森病、精神分裂症、药物成瘾和注意力缺陷多动障碍（ADHD）有关，这突出了D2自身受体在调节多巴胺系统中的重要性。本综述将总结多巴胺自身受体的细胞作用，并讨论最近的进展，这些进展加深了我们对D2受体控制多巴胺传递机制的理解。
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J Neurosci. 2013 Aug 21;33(34):13861-72. doi: 10.1523/JNEUROSCI.5099-12.2013.
2
Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area.D2 多巴胺受体功能缺失可调节腹侧被盖区可卡因诱导的谷氨酸能突触易化。
J Neurosci. 2013 Jul 24;33(30):12329-36. doi: 10.1523/JNEUROSCI.0809-13.2013.
3
Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S.通过病毒介导的受体恢复使D2基因敲除突变小鼠中多巴胺D2受体介导的反应正常化：比较D2L和D2S。
Neuroscience. 2013 Sep 17;248:479-87. doi: 10.1016/j.neuroscience.2013.06.035. Epub 2013 Jun 27.
4
Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor.由 G 蛋白偶联受体介导的自发性抑制性突触电流。
Neuron. 2013 Jun 5;78(5):807-12. doi: 10.1016/j.neuron.2013.04.013.
5
X-ray structure of the mammalian GIRK2-βγ G-protein complex.哺乳动物 GIRK2-βγ 蛋白偶联 G 蛋白复合物的 X 射线结构。
Nature. 2013 Jun 13;498(7453):190-7. doi: 10.1038/nature12241. Epub 2013 Jun 5.
6
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Neuropharmacology. 2014 Jan;76 Pt B(0 0):351-9. doi: 10.1016/j.neuropharm.2013.03.019. Epub 2013 Apr 8.
7
Agonist high- and low-affinity states of dopamine D₂ receptors: methods of detection and clinical implications.多巴胺 D₂ 受体的激动剂高亲和态和低亲和态：检测方法及临床意义。
Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):135-54. doi: 10.1007/s00210-012-0817-0. Epub 2012 Dec 9.
8
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J Neurosci. 2012 Sep 26;32(39):13520-8. doi: 10.1523/JNEUROSCI.2745-12.2012.
9
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Brain Struct Funct. 2013 Sep;218(5):1159-76. doi: 10.1007/s00429-012-0452-z. Epub 2012 Aug 29.
10
Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.多巴胺 D2 受体对多巴胺合成和释放的双重调控：突触前和突触后。
J Neurosci. 2012 Jun 27;32(26):9023-34. doi: 10.1523/JNEUROSCI.0918-12.2012.
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