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抑郁症患者静脉注射促肾上腺皮质激素释放激素后醛固酮和促肾上腺皮质激素释放减少。

Blunted aldosterone and ACTH release after human CRH administration in depressed patients.

作者信息

Holsboer F, Gerken A, Stalla G K, Müller O A

出版信息

Am J Psychiatry. 1987 Feb;144(2):229-31. doi: 10.1176/ajp.144.2.229.

DOI:10.1176/ajp.144.2.229
PMID:3028185
Abstract

The authors measured pituitary adrenocortical responses to human corticotropin-releasing hormone (CRH) in 10 patients with a major depressive episode and 10 matched control subjects. Depressed patients had a significantly lower aldosterone and ACTH release, but cortisol and corticosterone responses were not different between groups.

摘要

作者对10例重度抑郁发作患者和10例匹配的对照受试者测量了垂体肾上腺皮质对人促肾上腺皮质激素释放激素（CRH）的反应。抑郁患者的醛固酮和促肾上腺皮质激素释放显著降低，但两组间皮质醇和皮质酮反应无差异。

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