Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Adv Exp Med Biol. 2021;1291:283-294. doi: 10.1007/978-3-030-56153-6_17.
Depressive and anxiety disorders affect a significant proportion of the global population and constitute one of the highest disease burdens worldwide. Conventional pharmacological treatments are traditionally the first line of therapy for individuals affected by these conditions although these are only successful approximately half of the time and are often associated with undesirable side effects. This review describes the use of the natural substance curcumin as a potential alternative treatment of these mental disorders. With this in mind, we analyzed the effects of curcumin in eight clinical studies of depression and five studies of anxiety and assessed these using psychiatric symptom scores and molecular biomarker readouts.
抑郁和焦虑障碍影响了全球相当大比例的人口，是全球疾病负担最高的疾病之一。传统的药物治疗通常是受这些疾病影响的人的一线治疗方法，尽管这些治疗方法只有大约一半的时间是有效的，而且常常伴随着不良的副作用。本综述描述了天然物质姜黄素作为这些精神障碍的潜在替代治疗方法的应用。有鉴于此，我们分析了姜黄素在八项抑郁症临床研究和五项焦虑症研究中的作用，并使用精神症状评分和分子生物标志物检测结果来评估这些作用。
