Department of Urology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Medical College, Seoul, South Korea.
Department of Biostatistics, Clinical Trial Center, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
BJU Int. 2019 Apr;123(4):669-675. doi: 10.1111/bju.14577. Epub 2018 Oct 29.
To investigate the association between lower urinary tract symptoms (LUTS) and cardiovascular disease (CVD) risk in women, as severe LUTS are known to be associated with CVD risk in men but few studies have focused on this issue in women.
A total of 1014 ostensibly healthy women, who participated in a voluntary health check in a health promotion centre from November 2013 to October 2015, were enrolled. LUTS were assessed using the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS). CVD risk scores were calculated using the Framingham risk score and the American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease (ASCVD) score. Correlation, partial correlation, and multiple logistic regression analyses were conducted.
The mean age and body mass index (BMI) of the women were 51 years and 22.6 kg/m , respectively. The ASCVD score showed significant positive correlations with IPSS items Question 2 (Q2), Q3, Q5, and Q7 (all P < 0.05), total IPSS (P = 0.001), IPSS storage (P = 0.006) and IPSS voiding symptoms scores (P = 0.001) based on partial correlation analysis after adjustment for BMI. For the OABSS, the ASCVD score showed significant positive correlations with OABSS items Q2, Q3, and Q4 (P < 0.001, P = 0.017, and P < 0.001, respectively) and total OABSS (P < 0.001). Multiple logistic regression analysis showed that the moderate-severe risk groups of the OABSS and IPSS were associated with the ASCVD risk score in adjusted models (P < 0.001) compared to the none-mild OABSS and mild IPSS groups. After adjustment for age and BMI, IPSS storage score was significantly related with the ASCVD risk score (B = 0.855, P = 0.016) CONCLUSIONS: LUTS, especially storage symptoms, might be risk factors for predicting future CVD risk in women. Further prospective or cohort studies are needed to validate this possibility.
探讨下尿路症状（LUTS）与女性心血管疾病（CVD）风险之间的关系，因为严重的 LUTS 已知与男性的 CVD 风险相关，但很少有研究关注女性的这一问题。
共有 1014 名看似健康的女性参加了 2013 年 11 月至 2015 年 10 月在健康促进中心进行的自愿健康检查。采用国际前列腺症状评分（IPSS）和膀胱过度活动症症状评分（OABSS）评估 LUTS。使用 Framingham 风险评分和美国心脏病学会/美国心脏协会动脉粥样硬化性心血管疾病（ASCVD）评分计算 CVD 风险评分。进行了相关性、偏相关性和多元逻辑回归分析。
女性的平均年龄和体重指数（BMI）分别为 51 岁和 22.6kg/m。ASCVD 评分与 IPSS 项目问题 2（Q2）、Q3、Q5 和 Q7 均呈显著正相关（均 P <0.05），总 IPSS（P=0.001）、IPSS 储存（P=0.006）和 IPSS 排尿症状评分（P=0.001）在调整 BMI 后，基于偏相关性分析。对于 OABSS，ASCVD 评分与 OABSS 项目 Q2、Q3 和 Q4 呈显著正相关（均 P<0.001，P=0.017 和 P<0.001）和总 OABSS（P<0.001）。多元逻辑回归分析表明，调整模型中，OABSS 和 IPSS 的中重度风险组与 ASCVD 风险评分相关（P<0.001），而中重度 OABSS 和轻度 IPSS 组则无关。在调整年龄和 BMI 后，IPSS 储存评分与 ASCVD 风险评分显著相关（B=0.855，P=0.016）。
LUTS，尤其是储存症状，可能是预测女性未来 CVD 风险的危险因素。需要进一步的前瞻性或队列研究来验证这种可能性。
