Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Low Urin Tract Symptoms. 2020 May;12(2):128-136. doi: 10.1111/luts.12292. Epub 2019 Oct 23.
To evaluate the relationship between frailty and lower urinary tract symptoms (LUTS), the association of frailty and LUTS remains unclear.
This cross-sectional study investigated LUTS and frailty in 710 individuals (249 men and 461 women, aged ≥60 years) who participated in the Iwaki Health Promotion Project between 2014 and 2015 in Hirosaki, Japan. Parameters of frailty were compared for individuals with mild and moderate to severe symptoms of LUTS. The International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) were used to evaluate LUTS. Frailty was evaluated by the frailty phenotype (FP), modified frailty index (mFI), and frailty discriminant score (FDS). The influence of frailty on LUTS was investigated by multivariate logistic regression analyses.
Frailty parameters of age, renal function, and lower physical activity were significantly associated with severity of IPSS and OABSS. FP and mFI were significantly associated with severity of OABSS and IPSS, respectively. The FDS was significantly associated with severity of IPSS and OABSS. FP, mFI, and FDS were significantly associated with severity of nocturia. Multivariate logistic regression analyses revealed that FDS was independently associated with the severity of IPSS, OABSS, and nocturia, whereas FP and mFI were significantly associated with the severity of nocturia alone.
Individuals with LUTS are potentially frailer than those without LUTS. Although the influence of frailty on LUTS is different depending on the measurement tool, attention for frailty is necessary for subjects with LUTS.
评估衰弱与下尿路症状（LUTS）之间的关系，衰弱与 LUTS 之间的关联尚不清楚。
本横断面研究调查了 2014 年至 2015 年期间在日本弘前市参加岩木健康促进计划的 710 名（249 名男性和 461 名女性，年龄≥60 岁）个体的 LUTS 和衰弱情况。比较了有轻度和中度至重度 LUTS 症状个体的衰弱参数。使用国际前列腺症状评分（IPSS）和膀胱过度活动症症状评分（OABSS）评估 LUTS。通过衰弱表型（FP）、改良衰弱指数（mFI）和衰弱判别评分（FDS）评估衰弱。通过多变量逻辑回归分析研究衰弱对 LUTS 的影响。
年龄、肾功能和较低体力活动的衰弱参数与 IPSS 和 OABSS 的严重程度显著相关。FP 和 mFI 分别与 OABSS 和 IPSS 的严重程度显著相关。FDS 与 IPSS 和 OABSS 的严重程度显著相关。FP、mFI 和 FDS 与夜尿症的严重程度显著相关。多变量逻辑回归分析显示，FDS 与 IPSS、OABSS 和夜尿症的严重程度独立相关，而 FP 和 mFI 仅与夜尿症的严重程度显著相关。
有 LUTS 的个体比没有 LUTS 的个体更容易衰弱。尽管衰弱对 LUTS 的影响因测量工具而异，但对于有 LUTS 的受试者，应关注衰弱问题。
