Pocovi-Gerardino G, Correa-Rodríguez M, Rubio J-L Callejas, Fernández R Ríos, Ortego-Centeno N, Rueda-Medina B
1 Instituto de Investigación Biosanitaria (IBS), Granada, Spain.
2 Universidad de Granada (UGR), Granada, Spain.
Biol Res Nurs. 2019 Jan;21(1):107-113. doi: 10.1177/1099800418803176. Epub 2018 Oct 3.
C-reactive protein (CRP) is commonly used as a biomarker for inflammation. Mild elevations of CRP have been seen in chronic autoimmune diseases like systemic lupus erythematosus (SLE), and CRP has been linked to an increased risk of cardiovascular events. Diet quality and certain dietary factors seem to influence CRP levels in healthy subjects. To date, the effect of diet on serum CRP in SLE has not been studied. Our aim was to investigate the relationship between dietary nutrients, antioxidant intake, and serum CRP in SLE.
A cross-sectional study was conducted among 91 patients with SLE. High-sensitivity hsCRP values were determined using an immuno-turbidimetry assay in a Beckman Coulter analyzer (AU5800). Dietary intake of macro- and micronutrients was assessed through a 24-hr diet recall. Antioxidant nutrient intake was evaluated using the dietary antioxidant quality score (DAQs). Linear regression models were used to investigate the relationships between serum hsCRP levels, dietary nutrient intake, and DAQs.
The mean serum hsCRP level observed (3.76 ± 6.68 mg/L) was above the established normal range. However, participating SLE patients had low-quality diets, and we found no significant correlations between dietary intake of macro- or micronutrients or antioxidant nutrient intake (DAQs) and serum CRP levels.
Our study reveals that participating SLE patients had a low-quality diet that did not influence inflammatory status measured using serum CRP levels. Further interventional studies with high-quality diets in this population are necessary to dissect the role of diet on CRP levels in SLE.
C反应蛋白（CRP）通常用作炎症的生物标志物。在系统性红斑狼疮（SLE）等慢性自身免疫性疾病中已观察到CRP轻度升高，且CRP与心血管事件风险增加有关。饮食质量和某些饮食因素似乎会影响健康受试者的CRP水平。迄今为止，尚未研究饮食对SLE患者血清CRP的影响。我们的目的是研究SLE患者饮食营养素、抗氧化剂摄入量与血清CRP之间的关系。
对91例SLE患者进行了一项横断面研究。使用贝克曼库尔特分析仪（AU5800）通过免疫比浊法测定高敏hsCRP值。通过24小时饮食回顾评估常量和微量营养素的饮食摄入量。使用饮食抗氧化质量评分（DAQs）评估抗氧化营养素摄入量。采用线性回归模型研究血清hsCRP水平、饮食营养素摄入量和DAQs之间的关系。
观察到的血清hsCRP平均水平（3.76±6.68mg/L）高于既定的正常范围。然而，参与研究的SLE患者饮食质量较差，我们发现常量或微量营养素的饮食摄入量或抗氧化营养素摄入量（DAQs）与血清CRP水平之间无显著相关性。
我们的研究表明，参与研究的SLE患者饮食质量较差，且饮食质量并未影响通过血清CRP水平衡量的炎症状态。有必要对该人群进行高质量饮食的进一步干预研究，以剖析饮食对SLE患者CRP水平的作用。
