Price Stephanie, Le Quynh Nhu, White Nicole D
Creighton University School of Pharmacy and Health Professions, Omaha, Nebraska.
Am J Lifestyle Med. 2017 Nov 9;12(1):34-37. doi: 10.1177/1559827617740825. eCollection 2018 Jan-Feb.
Preventing or delaying the conversion of prediabetes to overt diabetes can reduce mortality and morbidity rates, improve health-related quality of life, and reduce other comorbid complications associated with diabetes. Studies have shown that a modest weight loss is one strategy for preventing or delaying diabetes diagnosis. First-line therapy in preventing progression of prediabetes to overt diabetes is weight loss through lifestyle modifications; however, pharmacotherapy for weight loss may be initiated if lifestyle alone is ineffective. The purpose of this article is to describe the pharmacotherapeuptic options for weight loss that can be used in conjunction with lifestyle in the prevention or delay of diabetes in patients with prediabetes.
预防或延缓糖尿病前期转化为显性糖尿病可降低死亡率和发病率，改善健康相关生活质量，并减少与糖尿病相关的其他合并症。研究表明，适度减重是预防或延缓糖尿病诊断的一种策略。预防糖尿病前期进展为显性糖尿病的一线治疗方法是通过生活方式改变来减重；然而，如果仅靠生活方式干预无效，则可启动减重药物治疗。本文旨在描述可与生活方式相结合用于预防或延缓糖尿病前期患者发生糖尿病的减重药物治疗选择。
