Laitinen K, MacDonald E, Saano V
Arch Toxicol Suppl. 1986;9:51-4. doi: 10.1007/978-3-642-71248-7_6.
The development of rats was studied for 3 postnatal weeks after prenatal medication with diazepam (10 mg/kg/day), phenytoin (50 mg/kg/day), or tofizopam (50 mg/kg twice daily) given by gastric intubation from day 7 to 21 of pregnancy. The treatments had no effect on the litter size. There were also no differences between the groups in a battery of tests for development (negative geotaxis, righting reflex, cliff avoidance, rotarod, passive avoidance), but the activity spurt seen at postnatal days 18-21 was missing in pups of diazepam-treated mothers. The number of benzodiazepine receptors and their affinity for tritiated flunitrazepam developed similarly in all of the rat groups. Thus, the transient changes in motor development seen 2-3 weeks after birth of rats whose mothers received diazepam during pregnancy do not seem to be related to changes in ontogenesis of benzodiazepine receptors.
在妊娠第7天至21天经胃管给大鼠产前服用地西泮（10毫克/千克/天）、苯妥英（50毫克/千克/天）或托非唑泮（50毫克/千克，每日两次），然后对出生后3周内的大鼠发育情况进行研究。这些处理对窝仔数没有影响。在一系列发育测试（负趋地性、翻正反射、避崖、转棒、被动回避）中，各组之间也没有差异，但地西泮处理组母鼠所生幼崽在出生后第18 - 21天出现的活动激增现象缺失。所有大鼠组中苯二氮䓬受体的数量及其对氚标记氟硝西泮的亲和力发育情况相似。因此，孕期接受地西泮的大鼠出生后2 - 3周出现的运动发育短暂变化似乎与苯二氮䓬受体个体发生的变化无关。
