Rosen Jurij, Blau Tobias, Grau Stefan J, Barbe Michael T, Fink Gereon R, Galldiks Norbert
Department of Neurology, University of Cologne, Cologne, Germany.
Institute of Neuropathology, University of Cologne, Cologne, Germany.
Case Rep Oncol. 2018 Aug 28;11(2):591-600. doi: 10.1159/000492111. eCollection 2018 May-Aug.
The glioblastoma, a malignant human brain tumor, is known for its devastating intracranial progress and its dismal prognosis. Whereas treatment and research are most prominently focused on the primary tumor lesion, in recent years evidence has accumulated that points to the rare occurrence of extracranial glioblastoma metastases. We here present a case of a female patient with a known glioblastoma who was detected to harbor multiple metastases in the bones, lung, pleura, liver, mesentery, and the subcutaneous soft tissue. Pathogenetically, these metastatic lesions developed most probably after a local progression of the left temporal glioblastoma through the skull base, thus getting access to the systemic lymphatics. Similar cases of extensive glioblastoma metastization, their putative underlying mechanisms, and implications for clinical care are discussed.
胶质母细胞瘤是一种恶性人脑肿瘤，以其毁灭性的颅内进展和预后不良而闻名。虽然治疗和研究主要集中在原发性肿瘤病变上，但近年来有证据表明，颅外胶质母细胞瘤转移罕见。我们在此报告一例已知患有胶质母细胞瘤的女性患者，该患者被检测出在骨骼、肺、胸膜、肝脏、肠系膜和皮下软组织中有多处转移。从发病机制上讲，这些转移病变很可能是在左颞叶胶质母细胞瘤通过颅底局部进展后形成的，从而进入了全身淋巴管。本文讨论了广泛的胶质母细胞瘤转移的类似病例、其可能的潜在机制以及对临床护理的影响。
