Jensen Bente Rona, Malling Anne Sofie Bøgh, Morberg Bo Mohr, Gredal Ole, Bech Per, Wermuth Lene
Department of Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Case Rep Neurol. 2018 Aug 29;10(2):242-251. doi: 10.1159/000492486. eCollection 2018 May-Aug.
Bipolar pulsed electromagnetic stimulation applied to the brain (T-PEMF) is a non-pharmacological treatment which has been shown to stimulate nerve growth, attenuate nerve abnormalities, and improve microcirculation. We report on a 62-year-old, medically well-treated man with idiopathic Parkinson's disease. He was treated with T-PEMF, 30 min per day for three 8-week periods separated by two 1-week breaks. The disease made his handwriting impossible to read mainly due to small letters and lack of fluency. Forearm EMG measured during standardized conditions showed an involuntary spiky EMG pattern with regular burst activity (on his left side) at baseline. The intervention normalized the handwriting and forearm EMG. The UPDRS-motor score decreased from 25 to 17, and UPDRS-II-handwriting decreased from a pre-intervention value of 3 to 0 after the intervention. Finally, the patient reported improved fine motor function, less muscle stiffness, less muscle cramps and tingling, and less fatigue during the day in response to the T-PEMF treatment. The improved handwriting lasted for approximately 3 months after the treatment. Our results should be considered as preliminary, and large-scale, controlled studies are recommended to elucidate the therapeutic potential of long-term treatment with T-PEMF.
经颅双相脉冲电磁刺激（T-PEMF）是一种非药物治疗方法，已被证明能刺激神经生长、减轻神经异常并改善微循环。我们报告了一名62岁、接受过良好药物治疗的特发性帕金森病男性患者。他接受了T-PEMF治疗，每天30分钟，分三个8周疗程进行，中间间隔两个1周的休息期。该疾病导致他的笔迹难以辨认，主要原因是字母过小且书写不流畅。在标准化条件下测量的前臂肌电图显示，基线时（左侧）存在非自愿的尖峰肌电图模式，并伴有规律的爆发活动。干预后笔迹和前臂肌电图恢复正常。统一帕金森病评定量表运动评分从25降至17，统一帕金森病评定量表-II-笔迹评分从干预前的3降至干预后的0。最后，患者报告称，T-PEMF治疗后精细运动功能改善、肌肉僵硬减轻、肌肉痉挛和刺痛减少，白天疲劳感减轻。治疗后笔迹改善持续了约3个月。我们的结果应被视为初步结果，建议开展大规模对照研究以阐明T-PEMF长期治疗的潜在疗效。
