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1型神经纤维瘤病患儿髓母细胞瘤的自然病史

Natural History of Medulloblastoma in a Child with Neurofibromatosis Type I.

作者信息

Golpayegani Mehdi, Salari Farhad, Habibi Zohreh, Anbarlouei Mousarreza, Mahdavi Ali, Nejat Farideh

机构信息

Department of Neurosurgery, Shahid Beheshti University of Medical Science, Tehran, Iran.

Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran, Iran.

出版信息

Asian J Neurosurg. 2018 Jul-Sep;13(3):918-920. doi: 10.4103/ajns.AJNS_35_18.

DOI:10.4103/ajns.AJNS_35_18
PMID:30283582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6159073/
Abstract

Medulloblastoma is one of the common posterior fossa tumors in children. The natural history of this tumor in presymptomatic period is not well known. Widespread use of brain imaging has increased the detection of incidental brain tumors in totally asymptomatic persons. Here, we report a case of a 4-year-old boy with prenatal diagnosis of congenital brain abnormalities and neurofibromatosis type I. He underwent regular brain imaging to follow interhemispheric arachnoid cyst and ventriculomegaly that a posterior fossa tumor was discovered. The tumor size increased during time and became symptomatic after 28 months which was resected.

摘要

髓母细胞瘤是儿童常见的后颅窝肿瘤之一。该肿瘤在无症状期的自然病程尚不清楚。脑部影像学检查的广泛应用增加了在完全无症状人群中偶然发现脑肿瘤的几率。在此,我们报告一例4岁男孩,产前诊断为先天性脑异常和I型神经纤维瘤病。他接受了定期脑部影像学检查以监测大脑半球间蛛网膜囊肿和脑室扩大情况,在此期间发现了一个后颅窝肿瘤。肿瘤大小随时间增加,28个月后出现症状并接受了切除手术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/6159073/192325132bb1/AJNS-13-918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/6159073/e391dae441e8/AJNS-13-918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/6159073/ac3489760572/AJNS-13-918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/6159073/192325132bb1/AJNS-13-918-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/6159073/e391dae441e8/AJNS-13-918-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/6159073/ac3489760572/AJNS-13-918-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e6/6159073/192325132bb1/AJNS-13-918-g003.jpg

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本文引用的文献

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A medulloblastoma showing an unusually long doubling time: reflection of its singular nature.
Childs Nerv Syst. 2016 Jun;32(6):1153-6. doi: 10.1007/s00381-015-2997-7. Epub 2016 Jan 6.
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Natural history of a medulloblastoma: 30 months of wait and see in a child with a cerebellar incidentaloma.髓母细胞瘤的自然病史:一名小脑偶发瘤患儿30个月的观察等待期
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