Mine Y, Watanabe Y, Tawara S, Nonoyama S, Yokota Y, Kikuchi H
Arzneimittelforschung. 1986 Nov;36(11):1651-5.
Exudative cells in the peritoneal cavity of mice, particularly polymorphonuclear leukocytes significantly increased 1 day after intraperitoneal injection of Nocardia rubra cell wall skeleton (N-CWS). Macrophages and lymphocytes significantly increased 4 to 7 days after injection. N-CWS also enhanced peritoneal macrophage functions such as phagocytosis of latex particles, production of superoxide anion, production and secretion of lysosomal enzymes such as beta-glucuronidase, lysozyme and acid phosphatase, phagocytosis and intracellular killing of bacteria, and in vitro chemotaxis. The phagocytic function of the reticuloendothelial system was also enhanced. These results indicate that macrophages were activated in vivo by N-CWS.
给小鼠腹腔注射红色诺卡氏菌细胞壁骨架（N-CWS）1天后，小鼠腹腔内的渗出细胞，尤其是多形核白细胞显著增加。注射后4至7天，巨噬细胞和淋巴细胞显著增加。N-CWS还增强了腹腔巨噬细胞的功能，如吞噬乳胶颗粒、产生超氧阴离子、产生和分泌溶酶体酶（如β-葡萄糖醛酸酶、溶菌酶和酸性磷酸酶）、吞噬和细胞内杀灭细菌以及体外趋化性。网状内皮系统的吞噬功能也得到增强。这些结果表明，N-CWS在体内激活了巨噬细胞。
