Mine Y, Watanabe Y, Tawara S, Yokota Y, Kikuchi H
Arzneimittelforschung. 1986 Dec;36(12):1774-8.
The in vitro and in vivo effects of Nocardia rubra cell wall skeleton (N-CWS) on induction of serum ceruloplasmin, hemopexin, haptoglobin, complement and interferon in mice and guinea pigs are described. After intraperitoneal administration of N-CWS to mice, serum hemopexin increased markedly and also induced an increase of haptoglobin, but not of ceruloplasmin. The drug activated complement in vitro but did not affect serum complement level in guinea pigs. Intravenous N-CWS induced serum interferon in mice, although there were strain differences. Addition of N-CWS to mouse spleen cell culture also induced interferon. Intraperitoneal N-CWS increased peritoneal cells in mice: in particular polymorphonuclear leukocytes increased soon after dosing, followed by macrophages and lymphocytes. However, the drug did not affect peripheral leukocyte counts or alter peripheral cell population.
本文描述了红色诺卡氏菌细胞壁骨架（N-CWS）对小鼠和豚鼠血清铜蓝蛋白、血红素结合蛋白、触珠蛋白、补体及干扰素诱导的体内外效应。给小鼠腹腔注射N-CWS后，血清血红素结合蛋白显著增加，同时触珠蛋白也增加，但铜蓝蛋白未增加。该药物在体外可激活补体，但不影响豚鼠血清补体水平。静脉注射N-CWS可诱导小鼠产生血清干扰素，不过存在品系差异。将N-CWS添加到小鼠脾细胞培养物中也可诱导产生干扰素。腹腔注射N-CWS可增加小鼠腹腔细胞数量：给药后不久多形核白细胞尤其增加，随后巨噬细胞和淋巴细胞增加。然而，该药物不影响外周白细胞计数，也不改变外周细胞群体。
