O'Caoimh Rónán, Galluzzo Lucia, Rodríguez-Laso Ángel, Van der Heyden Johan, Ranhoff Anette Hylen, Lamprini-Koula Maria, Ciutan Marius, López-Samaniego Luz, Carcaillon-Bentata Laure, Kennelly Siobhán, Liew Aaron
Health Service Executive of Ireland (Social Care Division) and National University of Ireland (Discipline of Medicine), Galway, Ireland - Health Service Executive of Ireland (Social Care Division) and National University of Ireland (Discipline of Medicine), Galway, Ireland.
Dipartimento Malattie Cardiovascolari, Dismetaboliche e Invecchiamento, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 2018 Jul-Sep;54(3):226-238. doi: 10.4415/ANN_18_03_10.
Although frailty is common among community-dwelling older adults, its prevalence in Europe and how this varies between countries is unclear.
A systematic review and meta-analysis of literature on frailty prevalence in 22 European countries involved in the Joint Action ADVANTAGE was conducted.
Sixty-two papers, representing 68 unique datasets were included. Meta-analysis showed an overall estimated frailty prevalence of 18% (95% confidence interval, CI, 15-21%). The prevalence in community (n = 53) vs non-community based studies (n = 15) was 12% (95% CI 10-15%) and 45% (95% CI 27-63%), respectively. Pooled prevalence in community studies adopting a physical phenotype was 12% (95% CI 10-14%, n = 45) vs 16% (95% CI 7-29%, n = 8) for all other definitions. Sub-analysis of a subgroup of studies assessed as high-quality (n = 47) gave a pooled estimate of 17% (95% CI 13-21%).
The considerable and significant heterogeneity found warrants the development of common methodological approaches to provide accurate and comparable frailty prevalence estimates at population-level.
尽管衰弱在社区居住的老年人中很常见，但在欧洲其患病率以及各国之间的差异尚不清楚。
对参与联合行动“优势”的22个欧洲国家中有关衰弱患病率的文献进行了系统综述和荟萃分析。
纳入了62篇论文，代表68个独特的数据集。荟萃分析显示，总体估计的衰弱患病率为18%（95%置信区间，CI，15 - 21%）。社区研究（n = 53）与非社区研究（n = 15）中的患病率分别为12%（95% CI 10 - 15%）和45%（95% CI 27 - 63%）。采用身体表型的社区研究中的合并患病率为12%（95% CI 10 - 14%，n = 45），而所有其他定义的合并患病率为16%（95% CI 7 - 29%，n = 8）。对被评估为高质量的一组研究（n = 47）进行亚分析，得出的合并估计值为17%（95% CI 13 - 21%）。
发现的相当大且显著的异质性有必要开发通用的方法学方法，以便在人群层面提供准确且可比的衰弱患病率估计值。
