O'Caoimh Rónán, Galluzzo Lucia, Rodríguez-Laso Ángel, Van der Heyden Johan, Ranhoff Anette Hylen, Carcaillon-Bentata Laure, Beltzer Nathalie, Kennelly Siobhán, Liew Aaron
Health Service Executive of Ireland (Social Care Division) and National University of Ireland (Discipline of Medicine), Galway, Ireland.
Dipartimento Malattie Cardiovascolari, Dismetaboliche e Invecchiamento, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 2018 Jul-Sep;54(3):246-252. doi: 10.4415/ANN_18_03_12.
Frailty is a dynamic syndrome and may be reversible. Despite this, little is known about trajectories or transitions between different stages of frailty.
A systematic review was conducted, selecting studies reporting frailty trajectories or transition states for adults in any settings in European ADVANTAGE Joint Action Member States.
Only three papers were included. Data were from longitudinal community-based cohorts in the United Kingdom, Netherlands and Italy. The English study investigated the effect of physical activity on the progression of frailty over a 10-year period. Two presented data on the proportion of participants experiencing at least one frailty transition over time (32.6% in the Italian sample aged ≥ 65 years followed for 4.4 years; 34.3% in the Dutch sample aged 65-75 years, followed for 2 years).
Data on frailty trajectories and transition states were limited and heterogeneous. Well-designed prospective studies and harmonized approaches to data collection are now needed.
衰弱是一种动态综合征，可能是可逆的。尽管如此，对于衰弱不同阶段之间的轨迹或转变了解甚少。
进行了一项系统综述，筛选在欧洲ADVANTAGE联合行动成员国任何环境下报告成人衰弱轨迹或转变状态的研究。
仅纳入了三篇论文。数据来自英国、荷兰和意大利基于社区的纵向队列研究。英国的研究调查了10年间身体活动对衰弱进展的影响。另外两篇论文呈现了随时间推移经历至少一次衰弱转变的参与者比例的数据（≥65岁的意大利样本随访4.4年，该比例为32.6%；65 - 75岁的荷兰样本随访2年，该比例为34.3%）。
关于衰弱轨迹和转变状态的数据有限且参差不齐。现在需要设计良好的前瞻性研究以及统一的数据收集方法。
