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本文引用的文献

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The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products.使用高效液相色谱法来阐明速尿及其代谢产物的代谢和尿排泄情况。
Acta Pharmacol Toxicol (Copenh). 1981 Sep;49(3):223-9. doi: 10.1111/j.1600-0773.1981.tb00897.x.
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Determining the probability of an important difference in bioavailability.
Clin Pharmacol Ther. 1980 Aug;28(2):247-52. doi: 10.1038/clpt.1980.157.
3
Implications of intraindividual variability in bioavailability studies of furosemide.速尿生物利用度研究中个体内变异性的影响。
Eur J Clin Pharmacol. 1984;27(5):595-602. doi: 10.1007/BF00556898.
4
Enalapril: a new angiotensin-converting enzyme inhibitor in chronic heart failure: acute and chronic hemodynamic evaluations.依那普利:一种用于慢性心力衰竭的新型血管紧张素转换酶抑制剂:急性和慢性血流动力学评估
J Am Coll Cardiol. 1983 Nov;2(5):865-71. doi: 10.1016/s0735-1097(83)80233-2.
5
Effects of enalapril, a new converting enzyme inhibitor, in hypertension.新型转换酶抑制剂依那普利对高血压的作用。
Clin Pharmacol Ther. 1982 Jul;32(1):48-53. doi: 10.1038/clpt.1982.125.
6
Antihypertensive activity of N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro (MK-421), an orally active converting enzyme inhibitor.N-[(S)-1-(乙氧羰基)-3-苯丙基]-L-丙氨酸-L-脯氨酸(MK-421),一种口服活性转化酶抑制剂的降压活性
J Pharmacol Exp Ther. 1981 Mar;216(3):558-66.
7
The physiological disposition and metabolism of enalapril maleate in laboratory animals.马来酸依那普利在实验动物体内的生理处置与代谢
Drug Metab Dispos. 1982 Jan-Feb;10(1):15-9.
8
The clinical pharmacology of enalapril.依那普利的临床药理学。
J Hypertens Suppl. 1983 Oct;1(1):65-70.
9
Blood pressure, plasma volume, and catecholamine levels during enalapril therapy in blacks with hypertension.
Clin Pharmacol Ther. 1984 Dec;36(6):731-7. doi: 10.1038/clpt.1984.250.
10
Enalapril (MK421) activation in man: importance of liver status.依那普利(MK421)在人体中的激活:肝脏状态的重要性。
Br J Clin Pharmacol. 1985 May;19(5):701-4. doi: 10.1111/j.1365-2125.1985.tb02699.x.

依那普利与速尿之间不存在药代动力学相互作用。

Absence of a pharmacokinetic interaction between enalapril and frusemide.

作者信息

Van Hecken A M, Verbesselt R, Buntinx A, Cirillo V J, De Schepper P J

出版信息

Br J Clin Pharmacol. 1987 Jan;23(1):84-7. doi: 10.1111/j.1365-2125.1987.tb03013.x.

DOI:10.1111/j.1365-2125.1987.tb03013.x
PMID:3028456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1386144/
Abstract

Single doses of enalapril maleate 10 mg and frusemide 80 mg do not significantly affect the pharmacokinetics of each other when taken concomitantly. Their concomitant use may be associated with more adverse effects than with the individual entities.

摘要

单剂量服用10毫克马来酸依那普利和80毫克速尿时,两者同时服用不会显著影响彼此的药代动力学。与单独使用相比,它们同时使用可能会产生更多不良反应。