血管紧张素转换酶抑制剂雷米普利对哮喘患者支气管对吸入组胺和缓激肽反应的影响。
The effect of an angiotensin converting enzyme inhibitor, ramipril, on bronchial responses to inhaled histamine and bradykinin in asthmatic subjects.
作者信息
Dixon C M, Fuller R W, Barnes P J
出版信息
Br J Clin Pharmacol. 1987 Jan;23(1):91-3. doi: 10.1111/j.1365-2125.1987.tb03015.x.
Abstract
The effect of a potent inhibitor of angiotensin-converting enzyme, ramipril, was studied on both inhaled histamine and bradykinin-induced bronchoconstriction in six male, normotensive, mild asthmatic subjects. Oral administration of 10 mg ramipril caused no change in lung function or airway reactivity to inhaled histamine or bradykinin despite achieving adequate reduction in angiotensin-converting enzyme activity.
摘要
在六名血压正常、轻度哮喘的男性受试者中，研究了强效血管紧张素转换酶抑制剂雷米普利对吸入组胺和缓激肽诱导的支气管收缩的影响。口服10毫克雷米普利后，尽管血管紧张素转换酶活性得到了充分降低，但肺功能或气道对吸入组胺或缓激肽的反应性并未改变。
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