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血管紧张素转换酶抑制剂雷米普利对哮喘患者支气管对吸入组胺和缓激肽反应的影响。

The effect of an angiotensin converting enzyme inhibitor, ramipril, on bronchial responses to inhaled histamine and bradykinin in asthmatic subjects.

作者信息

Dixon C M, Fuller R W, Barnes P J

出版信息

Br J Clin Pharmacol. 1987 Jan;23(1):91-3. doi: 10.1111/j.1365-2125.1987.tb03015.x.

DOI:10.1111/j.1365-2125.1987.tb03015.x
PMID:3028458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1386146/
Abstract

The effect of a potent inhibitor of angiotensin-converting enzyme, ramipril, was studied on both inhaled histamine and bradykinin-induced bronchoconstriction in six male, normotensive, mild asthmatic subjects. Oral administration of 10 mg ramipril caused no change in lung function or airway reactivity to inhaled histamine or bradykinin despite achieving adequate reduction in angiotensin-converting enzyme activity.

摘要

在六名血压正常、轻度哮喘的男性受试者中，研究了强效血管紧张素转换酶抑制剂雷米普利对吸入组胺和缓激肽诱导的支气管收缩的影响。口服10毫克雷米普利后，尽管血管紧张素转换酶活性得到了充分降低，但肺功能或气道对吸入组胺或缓激肽的反应性并未改变。

相似文献

1
The effect of an angiotensin converting enzyme inhibitor, ramipril, on bronchial responses to inhaled histamine and bradykinin in asthmatic subjects.血管紧张素转换酶抑制剂雷米普利对哮喘患者支气管对吸入组胺和缓激肽反应的影响。
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Increased cough reflex associated with angiotensin converting enzyme inhibitor cough.与血管紧张素转换酶抑制剂所致咳嗽相关的咳嗽反射增强。
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Br Med J (Clin Res Ed). 1988 Jan 9;296(6615):86-8. doi: 10.1136/bmj.296.6615.86.
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本文引用的文献

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A new method for computer-assisted determination of airways resistance.一种计算机辅助测定气道阻力的新方法。
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Pharmacology of bradykinin and related kinins.缓激肽及相关激肽的药理学
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Tolerance and pharmacodynamics of the angiotensin converting enzyme inhibitor 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2- azabicyclo[3.3.0]octane-3-carboxylic acid (Hoe 498) in healthy volunteers.血管紧张素转换酶抑制剂2-[N-[(S)-1-乙氧羰基-3-苯基丙基]-L-丙氨酰]-(1S,3S,5S)-2-氮杂双环[3.3.0]辛烷-3-羧酸（Hoe 498）在健康志愿者中的耐受性和药效学
Arzneimittelforschung. 1984;34(10B):1448-51.
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In vivo and in vitro effect of bradykinin on bronchial motor tone in normal subjects and patients with airways obstruction.缓激肽对正常受试者和气道阻塞患者支气管运动张力的体内及体外效应。
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Cough associated with the use of captopril.与使用卡托普利相关的咳嗽。
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Cough and wheeze caused by inhibitors of angiotensin-converting enzyme.
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A continuous monitoring spectrophotometric method for the measurement of angiotensin-converting enzyme in human serum.一种用于测定人血清中血管紧张素转换酶的连续监测分光光度法。
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