Wang Jinguo, Wang Na, Zhou Honglan, Wang Yuanyuan
Department of Urology, The First Hospital of Jilin University, Changchun, China. E-mail.
Saudi Med J. 2018 Oct;39(10):1023-1027. doi: 10.15537/smj.2018.10.22852.
To determine the efficacy of preemptive hydromorphone for laparoscopic radical gastrectomy. Methods: The present prospective and double-blinded study was performed in the The First Hospital, Jilin University, Changchun, China, between July 2017 and April 2018. Fifty patients scheduled for laparoscopic radical gastrectomy were equally randomized into 2 groups, which were administrated different drugs 10 minutes before surgery. Group P (the preemptive hydromorphone group) was administrated 2 mg hydromorphone (2 mL), and Group C (the control group) was administrated 2 mL normal saline intravenously. A standardized general anesthesia were conducted. Blood pressure and heart rate, postoperative morphine consumption, pain intensity, sedation status, and side effects were recorded. Results: Group C had larger intraoperative hemodynamic changes, higher postoperative visual analogue scale score, more morphine consumption and lower overall satisfaction degree than Group P. No difference was found between the 2 groups in sedation status and adverse effects. Conclusion: Preoperative 2 mg hydromorphone could reduce intraoperative changes of blood pressure and heart rate, postoperative pain intensity, and morphine consumption without an increase of adverse effects.
确定超前使用氢吗啡酮用于腹腔镜根治性胃切除术的疗效。方法：本前瞻性双盲研究于2017年7月至2018年4月在中国长春吉林大学第一医院进行。50例计划行腹腔镜根治性胃切除术的患者被随机均分为2组，在手术前10分钟给予不同药物。P组（超前使用氢吗啡酮组）静脉注射2mg氢吗啡酮（2mL），C组（对照组）静脉注射2mL生理盐水。实施标准化全身麻醉。记录血压、心率、术后吗啡用量、疼痛强度、镇静状态及副作用。结果：与P组相比，C组术中血流动力学变化更大，术后视觉模拟评分更高，吗啡用量更多，总体满意度更低。两组在镇静状态及不良反应方面无差异。结论：术前使用2mg氢吗啡酮可减少术中血压和心率变化、术后疼痛强度及吗啡用量，且不增加不良反应。
