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从臀肌脓肿到破坏性自体三尖瓣心内膜炎的路邓葡萄球菌感染

Staphylococcus lugdunensis from gluteal abscess to destructive native triple valve endocarditis.

作者信息

Al Majid Fahad M

机构信息

King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail:.

出版信息

Saudi Med J. 2018 Oct;39(10):1050-1053. doi: 10.15537/smj.2018.10.22905.

DOI:10.15537/smj.2018.10.22905
PMID:30284590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6201034/
Abstract

We herein present the case of a 43-year-old male diabetic patient who presented with an aggressive form of infective endocarditis involving the tricuspid, mitral and aortic valves following a gluteal abscess due to infection with Staphylococcus lugdunensis. This coagulase-negative organism which is generally considered a component of the normal flora of the skin has however recently emerged as an unusually virulent pathogen responsible for both nosocomial and community-acquired infections. The case demonstrates the importance of paying utmost attention and ensuring a logical conclusion to the identification of persistent coagulase-negative blood cultures. In addition, it also shows the importance of early identification of this organism and aggressive antibiotic administration to avert endocarditis because of the unusual virulence of the organism. Staphylococcus lugdunensis is rarely a clinical specimen contaminant, and its isolation warrants further investigation and concerted treatment.

摘要

我们在此报告一例43岁男性糖尿病患者的病例,该患者因感染路邓葡萄球菌导致臀肌脓肿后,出现了一种侵袭性感染性心内膜炎,累及三尖瓣、二尖瓣和主动脉瓣。这种凝固酶阴性的微生物通常被认为是皮肤正常菌群的一部分,但最近已成为一种异常毒力的病原体,可导致医院获得性感染和社区获得性感染。该病例表明,对于持续的凝固酶阴性血培养结果的鉴定,必须给予高度关注并确保得出合理结论。此外,由于该微生物具有异常的毒力,它还显示了早期识别该微生物并积极给予抗生素治疗以避免心内膜炎的重要性。路邓葡萄球菌很少是临床标本的污染物,其分离需要进一步调查和协同治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/6201034/8608b32e657f/SaudiMedJ-39-1050-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/6201034/2b95b4982ce2/SaudiMedJ-39-1050-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/6201034/8608b32e657f/SaudiMedJ-39-1050-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/6201034/2b95b4982ce2/SaudiMedJ-39-1050-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/193b/6201034/8608b32e657f/SaudiMedJ-39-1050-g002.jpg

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本文引用的文献

1
Staphylococcus lugdunensis Infections of the Skin and Soft Tissue: A Case Series and Review.路邓葡萄球菌皮肤及软组织感染:病例系列报道与综述
Dermatol Ther (Heidelb). 2017 Dec;7(4):555-562. doi: 10.1007/s13555-017-0202-5. Epub 2017 Oct 11.
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endocarditis with destruction of the ventricular septum and multiple native valves.伴有室间隔破坏及多个自身瓣膜病变的心内膜炎
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Staphylococcus lugdunensis: a rare but destructive cause of coagulase-negative staphylococcus infective endocarditis.
与表皮葡萄球菌和金黄色葡萄球菌菌血症患者相比,凝固酶阴性葡萄球菌菌血症成人患者的特征和结局:日本一所大学医院 16 年回顾性研究。
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路邓葡萄球菌:凝固酶阴性葡萄球菌感染性心内膜炎的罕见但破坏性病因。
Eur Heart J Acute Cardiovasc Care. 2014 Sep;3(3):275-80. doi: 10.1177/2048872614523350. Epub 2014 Feb 12.
4
The major autolysin of Staphylococcus lugdunensis, AtlL, is involved in cell separation, stress-induced autolysis and contributes to bacterial pathogenesis.金黄色葡萄球菌的主要自溶素 AtlL 参与细胞分离、应激诱导的自溶,并有助于细菌的发病机制。
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5
Staphylococcus lugdunensis: low prevalence and clinical significance in a pediatric microbiology laboratory.路邓葡萄球菌:儿科微生物实验室中的低流行率和临床意义。
Pediatr Infect Dis J. 2013 Jan;32(1):87-9. doi: 10.1097/INF.0b013e3182755f58.
6
Staphylococcus lugdunensis in several niches of the normal skin flora.在正常皮肤菌群的多个生态位中存在凝固酶阴性葡萄球菌(Staphylococcus lugdunensis)。
Clin Microbiol Infect. 2010 Apr;16(4):385-8. doi: 10.1111/j.1469-0691.2009.02813.x. Epub 2009 Jun 6.
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Staphylococcus lugdunensis infective endocarditis: description of 10 cases and analysis of native valve, prosthetic valve, and pacemaker lead endocarditis clinical profiles.路邓葡萄球菌感染性心内膜炎:10例病例描述及天然瓣膜、人工瓣膜和起搏器导线心内膜炎临床特征分析
Heart. 2005 Feb;91(2):e10. doi: 10.1136/hrt.2004.040659.
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Staphylococcus lugdunensis endocarditis--the hidden peril of coagulase-negative staphylococcus in blood cultures.路邓葡萄球菌心内膜炎——血培养中凝固酶阴性葡萄球菌的潜在危险
Eur J Clin Microbiol Infect Dis. 2003 Aug;22(8):489-91. doi: 10.1007/s10096-003-0953-z. Epub 2003 Jul 4.
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Frequency of isolation of Staphylococcus lugdunensis among staphylococcal isolates causing endocarditis: a 20-year experience.在引起心内膜炎的葡萄球菌分离株中卢氏葡萄球菌的分离频率:20年经验
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