Musalem Hebah Mohammadsalam, Alshaikh Aljoharah Abdulaziz, Tuleimat Lin M, Alajlan Saad
Dr. Hebah Mohammadsalam Musalem, Department of Medicine,, Alfaisal University, Riyadh 11551,, Saudi Arabia, T: 966533112656,
Ann Saudi Med. 2018 Sep-Oct;38(5):376-380. doi: 10.5144/0256-4947.2018.376.
We used a topical formulation of sirolimus for treating port wine stain (PWS). Although pulsed dye laser (PDL) is the current treatment of choice for PWS, fast neovascularization after treatment is a major drawback. With PDL therapy there has been insufficient improvement and frustrating side effects. The objective was to study the efficacy and safety of combining topical sirolimus with PDL as dual therapy in managing PWS. We report five PWS cases that were treated with PDL initially, followed by 0.5-1% topical sirolimus. With dual therapy there was significant improvement over a shorter duration. More published studies of topical sirolimus are needed to clarify the role of dual therapy in managing PWS associated with capillary malformations. We encourage further prospective and comparative studies with a larger sample size.
我们使用西罗莫司的局部制剂来治疗葡萄酒色斑（PWS）。尽管脉冲染料激光（PDL）是目前治疗PWS的首选方法，但治疗后快速的血管新生是一个主要缺点。PDL治疗存在改善不足和令人沮丧的副作用。目的是研究局部应用西罗莫司与PDL联合作为双重疗法治疗PWS的疗效和安全性。我们报告了5例PWS病例，最初采用PDL治疗，随后使用0.5 - 1%的局部西罗莫司。双重疗法在更短的时间内有显著改善。需要更多关于局部西罗莫司的已发表研究来阐明双重疗法在治疗与毛细血管畸形相关的PWS中的作用。我们鼓励进行更大样本量的进一步前瞻性和对比研究。
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