Cota Daniela
INSERM U862, Avenir group Physiopathology of Energy Balance and Obesity, Université de Bordeaux 2, Bordeaux, France.
Physiol Behav. 2009 Jul 14;97(5):520-4. doi: 10.1016/j.physbeh.2009.03.006. Epub 2009 Mar 16.
Energy balance is guaranteed by a complex circuitry that in the brain, and in the hypothalamus in particular, integrates and coordinates several types of signals, including hormones and nutrients, so to match energy expenditure to energy needs. Similar to individual cells, the hypothalamus also profits from intracellular pathways known to work as fuel sensors to maintain energy balance. The mammalian target of rapamycin complex 1 (mTORC1) pathway has been recently implicated in such function, due to its ability to integrate nutrient and hormonal signals to control food intake and body weight. This review therefore describes recent advances made in understanding the role of the hypothalamic mTORC1 pathway in energy balance regulation and its possible contribution to the metabolic dysregulation associated with diet-induced obesity.
能量平衡由大脑中一个复杂的回路保证，尤其是下丘脑，它整合并协调多种信号，包括激素和营养物质，从而使能量消耗与能量需求相匹配。与单个细胞类似，下丘脑也受益于已知作为燃料传感器发挥作用以维持能量平衡的细胞内途径。雷帕霉素复合物1（mTORC1）途径最近因其能够整合营养和激素信号以控制食物摄入和体重而被认为具有这种功能。因此，本综述描述了在理解下丘脑mTORC1途径在能量平衡调节中的作用及其对与饮食诱导肥胖相关的代谢失调的可能贡献方面取得的最新进展。
