Department of Molecular Biology and National Centers of Competence in Research and Frontiers in Genetics and Chemical Biology, University of Geneva, Geneva, CH-1211, Switzerland.
Genetics. 2011 Dec;189(4):1177-201. doi: 10.1534/genetics.111.133363.
TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.
雷帕霉素靶蛋白（TOR）是一种高度保守的蛋白激酶，在基础生物学和临床生物学中都很重要。在基础生物学中，TOR 是一种营养感应的、细胞生长和衰老的中央控制器。在临床生物学中，TOR 与许多疾病有关，也是雷帕霉素（用于三个不同治疗领域的药物）的靶点。酿酒酵母（Saccharomyces cerevisiae）在 TOR 的发现及其功能阐明中都发挥了重要作用。在这里，我们综述了酿酒酵母中的 TOR 信号网络。
