Calvo J R, Goberna R, Guerrero J M
Biosci Rep. 1986 Aug;6(8):727-33. doi: 10.1007/BF01116540.
Thymic peptide thymosin alpha 1 (10(-9) to 3 X 10(-7) M) is shown to inhibit the specific binding of [125I]VIP to rat blood mononuclear cells and liver plasma membranes. Thymosin alpha 1 was 160 and 6250 times less potent that VIP at inhibiting [125I]VIP binding to blood mononuclear cells and liver plasma membranes, respectively. Thymosin alpha 1 (10(-10) to 10(-7) M) was weak in stimulating adenylate cyclase activity. Its efficacy is about 25% and 27% that of native VIP in blood mononuclear cells and liver plasma membranes, respectively. Thymosin alpha 1 may behave as a partial VIP agonist in rat.
胸腺肽α1（10^(-9)至3×10^(-7)M）可抑制[125I]血管活性肠肽（VIP）与大鼠血液单核细胞及肝细胞膜的特异性结合。在抑制[125I]VIP与血液单核细胞及肝细胞膜结合方面，胸腺肽α1的效力分别比VIP低160倍和6250倍。胸腺肽α1（10^(-10)至10^(-7)M）刺激腺苷酸环化酶活性的作用较弱。在血液单核细胞和肝细胞膜中，其效力分别约为天然VIP的25%和27%。胸腺肽α1在大鼠体内可能表现为部分VIP激动剂。
