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[健康女性血清中与乳腺癌病毒(MMTV)蛋白相互作用的抗体]

[Antibodies interacting with the proteins of the mammary cancer virus (MMTV) in the sera of healthy women].

作者信息

Litvinov S V, Riabykh T P, Kriukova I N, Apraskina A V

出版信息

Biull Eksp Biol Med. 1987 Feb;103(2):194-6.

PMID:3028532
Abstract

Using enzyme-linked immunoassay (ELISA), sera of 405 women without breast cancer were screened for the presence of antibodies to mouse mammary tumour virus proteins. 16 donors with positive sera were identified (3.96 +/- 0.97%). An attempt was made to establish the correlation between the age, ovarian Activity, benign breast disease and other factors and the appearance of antibodies to mouse mammary tumour virus. No statistically significant differences have been revealed among women aged 20-29 (3.92%), 30-39 (4.69%), 40-49 (4.08%) and 50-59 (2.38%), as well as in premenopausal (4.31%) and postmenopausal (4.5%) women and women with simple fibromatous disease (4.76%) and without any mammary gland pathology.

摘要

采用酶联免疫吸附测定(ELISA)法,对405名无乳腺癌的女性血清进行检测,以筛查抗小鼠乳腺肿瘤病毒蛋白抗体的存在情况。确定了16名血清呈阳性的捐献者(3.96 +/- 0.97%)。试图建立年龄、卵巢活性、乳腺良性疾病及其他因素与抗小鼠乳腺肿瘤病毒抗体出现之间的相关性。在20 - 29岁(3.92%)、30 - 39岁(4.69%)、40 - 49岁(4.08%)和50 - 59岁(2.38%)的女性中,以及绝经前(4.31%)和绝经后(4.5%)的女性、患有单纯纤维瘤病(4.76%)和无任何乳腺病理改变的女性中,均未发现统计学上的显著差异。

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