Tentolouris Anastasios, Eleftheriadou Ioanna, Tsilingiris Dimitrios, Anastasiou Ioanna A, Kosta Ourania A, Mourouzis Iordanis, Kokkinos Alexandros, Pantos Constantinos, Katsilambros Nikolaos, Tentolouris Nikolaos
Diabetes Center, National and Kapodistrian University of Athens, Athens, Greece.
Department of Pharmacology, National and Kapodistrian University of Athens, Athens Greece.
Horm Metab Res. 2018 Nov;50(11):803-810. doi: 10.1055/a-0748-6170. Epub 2018 Oct 4.
Irisin is a myokine that increases energy expenditure. In this cross-sectional study, we examined for differences in plasma irisin concentrations between subjects with type 1 diabetes mellitus and healthy individuals and searched for associations between plasma irisin levels and clinical and biochemical characteristics as well as self-reported physical activity. A total of 79 subjects with type 1 diabetes [age 38.2±12.5 years, men/women (n): 27/52], were consecutively recruited. Moreover, 53 healthy controls, matched for age and body mass index with those with diabetes were recruited. Plasma irisin was measured with ELISA. Participants were asked about their physical activity during the last week. We also measured trunk and visceral fat. Circulating irisin levels were lower in subjects with diabetes than in controls [median value (interquartile range): 53.0 (35.2, 106.3) vs. 178.1 (42.6, 641.6) ng/ml, respectively, p<0.001]. In the group of diabetes, univariate analysis showed that irisin levels were associated with waist circumference (beta=-0.283, p=0.023), serum triglycerides (beta=-0.282, p=0.031), and trunk fat (beta=-0.324, p=0.012). In multivariate analysis after adjustment for potential confounders, irisin levels were associated independently only with waist circumference (beta=-0.403, p=0.005). Among controls, multivariate analysis demonstrated that irisin levels were associated with pack-years of smoking (beta=-0.563, p=0.012) and fasting triglycerides (beta=-0.338, p=0.041). Circulating irisin levels were lower in subjects with diabetes in comparison with healthy-matched controls. In conclusion, plasma irisin concentrations in subjects with diabetes were associated with waist circumference, while in controls with serum triglycerides and pack-years of smoking.
鸢尾素是一种可增加能量消耗的肌动蛋白。在这项横断面研究中，我们检测了1型糖尿病患者与健康个体之间血浆鸢尾素浓度的差异，并探寻血浆鸢尾素水平与临床和生化特征以及自我报告的身体活动之间的关联。共连续招募了79例1型糖尿病患者[年龄38.2±12.5岁，男性/女性（n）：27/52]。此外，还招募了53名年龄和体重指数与糖尿病患者相匹配的健康对照者。采用酶联免疫吸附测定法（ELISA）检测血浆鸢尾素。询问参与者过去一周的身体活动情况。我们还测量了躯干和内脏脂肪。糖尿病患者的循环鸢尾素水平低于对照组[中位数（四分位间距）：分别为53.0（35.2，106.3）与178.1（42.6，641.6）ng/ml，p<0.001]。在糖尿病组中，单因素分析显示鸢尾素水平与腰围（β=-0.283，p=0.023）、血清甘油三酯（β=-0.282，p=0.031）和躯干脂肪（β=-0.324，p=0.012）相关。在对潜在混杂因素进行校正后的多因素分析中，鸢尾素水平仅独立与腰围相关（β=-0.403，p=0.005）。在对照组中，多因素分析表明鸢尾素水平与吸烟包年数（β=-0.563，p=0.012）和空腹甘油三酯（β=-0.338，p=0.041）相关。与健康匹配对照组相比，糖尿病患者的循环鸢尾素水平较低。总之，糖尿病患者的血浆鸢尾素浓度与腰围相关，而在对照组中与血清甘油三酯和吸烟包年数相关。
