从不吸烟者肺癌致癌作用的表观遗传流行病学研究的必要性。
Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers.
作者信息
Bae Jong-Myon
机构信息
Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea.
出版信息
J Prev Med Public Health. 2018 Sep;51(5):263-264. doi: 10.3961/jpmph.18.076. Epub 2018 Jul 8.
Abstract
Based on epidemiological and genomic characteristics, lung cancer in never smokers (LCNS) is a different disease from lung cancer in smokers. Based on current research, the main risk factor for LCNS may be air pollution. A recent case-control study in Koreans reported that nitrogen dioxide (NO2) may be a risk factor for LCNS. Additionally, a cohort study showed that exposure to NO2 was associated with significant hypomethylation. Thus, epigenetic epidemiology studies are needed in the near future to evaluate the carcinogenesis of LCNS according to chronic exposure to air pollution and/or viral infections.
摘要
基于流行病学和基因组特征，从不吸烟者的肺癌（LCNS）与吸烟者的肺癌是不同的疾病。根据目前的研究，LCNS的主要风险因素可能是空气污染。最近一项针对韩国人的病例对照研究报告称，二氧化氮（NO2）可能是LCNS的一个风险因素。此外，一项队列研究表明，接触NO2与显著的低甲基化有关。因此，在不久的将来需要进行表观遗传流行病学研究，以评估长期暴露于空气污染和/或病毒感染下LCNS的致癌作用。
相似文献
1
Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers.从不吸烟者肺癌致癌作用的表观遗传流行病学研究的必要性。
J Prev Med Public Health. 2018 Sep;51(5):263-264. doi: 10.3961/jpmph.18.076. Epub 2018 Jul 8.
2
New insights into the biology and development of lung cancer in never smokers-implications for early detection and treatment.从不吸烟者的角度探讨肺癌的生物学和发生机制——对早期检测和治疗的启示。
J Transl Med. 2023 Aug 31;21(1):585. doi: 10.1186/s12967-023-04430-x.
3
Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study.肺癌风险与居住环境空气污染暴露：一项基于韩国人群的病例对照研究。
Yonsei Med J. 2017 Nov;58(6):1111-1118. doi: 10.3349/ymj.2017.58.6.1111.
4
Long-term residential exposure to air pollution and lung cancer risk.长期居住在空气污染环境下与肺癌风险。
Epidemiology. 2013 Sep;24(5):762-72. doi: 10.1097/EDE.0b013e3182949ae7.
5
An evidence-based assessment for the association between long-term exposure to outdoor air pollution and the risk of lung cancer.长期暴露于室外空气污染与肺癌风险之间关联的循证评估。
Eur J Cancer Prev. 2016 May;25(3):163-72. doi: 10.1097/CEJ.0000000000000158.
6
Effects of long-term exposure to traffic-related air pollution on respiratory and cardiovascular mortality in the Netherlands: the NLCS-AIR study.长期暴露于交通相关空气污染对荷兰呼吸道和心血管疾病死亡率的影响：荷兰长期队列空气污染研究（NLCS-AIR研究）
Res Rep Health Eff Inst. 2009 Mar(139):5-71; discussion 73-89.
7
Air pollution and genomic instability: The role of particulate matter in lung carcinogenesis.空气污染与基因组不稳定性：颗粒物在肺癌发生中的作用。
Environ Pollut. 2017 Oct;229:412-422. doi: 10.1016/j.envpol.2017.06.019. Epub 2017 Jun 13.
8
Effects of short-term exposure to air pollution on hospital admissions of young children for acute lower respiratory infections in Ho Chi Minh City, Vietnam.越南胡志明市短期暴露于空气污染对幼儿急性下呼吸道感染住院率的影响。
Res Rep Health Eff Inst. 2012 Jun(169):5-72; discussion 73-83.
9
Effect of air pollution on lung cancer: a Poisson regression model based on vital statistics.空气污染对肺癌的影响：基于人口动态统计数据的泊松回归模型
Environ Health Perspect. 1994 Nov;102 Suppl 8(Suppl 8):41-5. doi: 10.1289/ehp.94102s841.
10
Air pollution.空气污染。
Chronic Dis Can. 2010;29(Suppl 2):144-63.
引用本文的文献
1
Serum Folate Levels and Lung Cancer Risk: A Meta- Epidemiological Study of Population-based Case-Control Studies.血清叶酸水平与肺癌风险：基于人群的病例对照研究的荟萃流行病学研究。
Asian Pac J Cancer Prev. 2020 Jun 1;21(6):1829-1833. doi: 10.31557/APJCP.2020.21.6.1829.
本文引用的文献
1
Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology.通过表观遗传流行病学解读过敏性疾病的卫生与微生物群落假说。
Epidemiol Health. 2018 Mar 10;40:e2018006. doi: 10.4178/epih.e2018006. eCollection 2018.
2
Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study.肺癌风险与居住环境空气污染暴露：一项基于韩国人群的病例对照研究。
Yonsei Med J. 2017 Nov;58(6):1111-1118. doi: 10.3349/ymj.2017.58.6.1111.
3
DNA methylation and exposure to ambient air pollution in two prospective cohorts.两项前瞻性队列研究中的DNA甲基化与暴露于环境空气污染情况
Environ Int. 2017 Nov;108:127-136. doi: 10.1016/j.envint.2017.08.006. Epub 2017 Aug 24.
4
Lung Adenocarcinoma in Never Smokers: Problems of Primary Prevention from Aspects of Susceptible Genes and Carcinogens.从不吸烟者的肺腺癌：从易感基因和致癌物角度看一级预防问题
Anticancer Res. 2016 Dec;36(12):6207-6224. doi: 10.21873/anticanres.11215.
5
Epigenetics-a potential mediator between air pollution and preterm birth.表观遗传学——空气污染与早产之间的潜在中介因素。
Environ Epigenet. 2016 Jan;2(1). doi: 10.1093/eep/dvv008. Epub 2016 Jan 12.
6
Modifiable risk factors of lung cancer in "never-smoker" women.“从不吸烟”女性患肺癌的可改变风险因素。
Epidemiol Health. 2015 Oct 29;37:e2015047. doi: 10.4178/epih/e2015047. eCollection 2015.
7
Air pollution and epigenetics: effects on SP-A and innate host defence in the lung.空气污染与表观遗传学：对肺表面活性物质相关蛋白 A 和固有宿主防御的影响。
Swiss Med Wkly. 2012 May 2;142:w13579. doi: 10.4414/smw.2012.13579. eCollection 2012.
8
Lung cancer in never smokers--a review.不吸烟人群中的肺癌——综述。
Eur J Cancer. 2012 Jun;48(9):1299-311. doi: 10.1016/j.ejca.2012.03.007. Epub 2012 Mar 28.
9
10
Lung cancer in never smokers--a different disease.从不吸烟者患肺癌——一种不同的疾病。
Nat Rev Cancer. 2007 Oct;7(10):778-90. doi: 10.1038/nrc2190.
Zotero 插件