Mizota Yuri, Kanemitsu Yukihide, Tsukamoto Shunsuke, Shida Dai, Ochiai Hiroki, Yamamoto Seiichiro
Division of Health Sociology, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo, Tokyo, 104-0045, Japan.
Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo, Tokyo, 104-0045, Japan.
BMC Cancer. 2018 Oct 4;18(1):953. doi: 10.1186/s12885-018-4830-7.
Many studies have shown that lifestyle factors such as diet, physical activity are related to the incidence of cancer. However, there are few studies on the association between lifestyle factors and cancer prognosis. To investigate the influence of lifestyle factors and psychosocial factors on prognosis, we started a prospective study of women with breast cancer, the Rainbow of KIBOU study-Breast (ROK Study-B) in 2007. As of February 2018, more than 6300 women have been enrolled, thus making this one of the world's largest cancer patient cohort studies. Based on the know-how obtained from this study, we started another new cohort study for colorectal cancer patient (ROK Study-C).
The ROK Study-C is a prospective observational study for colorectal cancer survivors at the National Cancer Center Hospital. Participants fill in several self-administrated questionnaires about lifestyle, psychosocial factors (including posttraumatic growth and benefit finding, support), and quality of life (QOL) 5 times in total: at diagnosis, 3 and 6 months, 1 and 5 years after surgery. CT-scans will be collected to assess body composition and obesity. We also use blood and cancer tissue from the Biobank. The primary endpoint is disease-free survival. The secondary endpoints are overall survival and health-related QOL. The planned sample size is 2000 and the follow-up period is 5 years after the last enrollment.
Recruitment began in December 2015 and the study is still ongoing. The ROK Study-C will contribute to improvements in patient prognosis and yield important evidence for colorectal cancer survivorship.
许多研究表明，饮食、体育活动等生活方式因素与癌症发病率相关。然而，关于生活方式因素与癌症预后之间关联的研究较少。为了调查生活方式因素和心理社会因素对预后的影响，我们于2007年启动了一项针对乳腺癌女性的前瞻性研究——“希望之虹”乳腺癌研究（ROK研究 - B）。截至2018年2月，已有6300多名女性入组，这使其成为世界上最大的癌症患者队列研究之一。基于从该研究中获得的经验，我们启动了另一项针对结直肠癌患者的新队列研究（ROK研究 - C）。
ROK研究 - C是一项针对国家癌症中心医院结直肠癌幸存者的前瞻性观察性研究。参与者总共需填写5次关于生活方式、心理社会因素（包括创伤后成长和益处发现、支持）以及生活质量（QOL）的自填式问卷：在诊断时、术后3个月、6个月、1年和5年。将收集CT扫描结果以评估身体成分和肥胖情况。我们还会使用生物样本库中的血液和癌症组织。主要终点是无病生存期。次要终点是总生存期和与健康相关的生活质量。计划样本量为2000，随访期为最后一名参与者入组后的5年。
招募工作于2015年12月开始，研究仍在进行中。ROK研究 - C将有助于改善患者预后，并为结直肠癌幸存者提供重要证据。
