Stephenson Lynette E, Bebb D Gwyn, Reimer Raylene A, Culos-Reed S Nicole
Faculty of Kinesiology, University of Calgary, 2500 University Dr. NW, Calgary Alberta, T2N 1N4, Canada.
BMC Gastroenterol. 2009 Jul 27;9:60. doi: 10.1186/1471-230X-9-60.
The relationship between colorectal cancer (CRC) risk and physical activity and dietary habits has been well-established, but less is known about the relationship between these behaviours and quality of life (QOL) post-diagnosis. Moreover, it is unknown whether this relationship is consistent across cancer stage or treatment setting. Thus, the purpose of this study was to assess current diet and physical activity behaviour in CRC survivors receiving systemic chemotherapy, and to examine potential associations between these behaviours and quality of life. A secondary purpose was to examine the association between social support, diet, and physical activity behaviour in this population.
Using a cross-sectional survey, 67 CRC survivors currently receiving chemotherapy in Calgary, Alberta completed the survey package. Measures included demographic and medical data, physical activity levels, diet behaviour, QOL, and social support.
In a largely metastatic sample (63%), approximately half were meeting national dietary guidelines (58%), less were meeting national physical activity guidelines (26%), and a small number were meeting both (17%). However, only 12.3% (n = 8) reported completely sedentary behaviour, and 7 of these 8 participants were receiving metastatic treatment. Neither behaviour was significantly associated with QOL or perceived social support. Furthermore, there were no significant QOL differences between those treated with palliative intent or adjuvant therapy. Important group differences emerged between those meeting and not meeting the guidelines, and associations between QOL, age, BMI, and provisions of social support.
These findings provide insight into lifestyle behaviours of CRC survivors currently receiving systemic chemotherapy, and the differences in perceived QOL as affected by severity of disease and treatment setting. Prospective studies in a larger sample of CRC survivors on chemotherapy are needed to confirm lifestyle behaviour patterns and identify factors related to QOL that are unique to this population, especially during metastatic treatment.
结直肠癌（CRC）风险与身体活动及饮食习惯之间的关系已得到充分证实，但对于这些行为与诊断后生活质量（QOL）之间的关系，人们了解较少。此外，尚不清楚这种关系在不同癌症阶段或治疗背景下是否一致。因此，本研究的目的是评估接受全身化疗的CRC幸存者当前的饮食和身体活动行为，并探讨这些行为与生活质量之间的潜在关联。第二个目的是研究该人群中社会支持、饮食和身体活动行为之间的关联。
采用横断面调查，艾伯塔省卡尔加里市67名正在接受化疗的CRC幸存者完成了调查问卷。测量指标包括人口统计学和医学数据、身体活动水平、饮食行为、生活质量和社会支持。
在一个主要为转移性样本（63%）中，约一半人符合国家饮食指南（58%），较少人符合国家身体活动指南（26%），只有少数人两者都符合（17%）。然而只有12.3%（n = 8）报告完全久坐行为，这8名参与者中有7名正在接受转移性治疗。这两种行为均与生活质量或感知到的社会支持无显著关联。此外，接受姑息治疗或辅助治疗的患者在生活质量方面无显著差异。在符合和不符合指南的人群之间出现了重要的组间差异，以及生活质量、年龄、体重指数和社会支持提供之间的关联。
这些发现为目前正在接受全身化疗的CRC幸存者的生活方式行为，以及受疾病严重程度和治疗背景影响的感知生活质量差异提供了见解。需要对更多接受化疗的CRC幸存者进行前瞻性研究，以确认生活方式行为模式，并确定该人群特有的与生活质量相关的因素，尤其是在转移性治疗期间。
