Masenga Sepiso K, Mweemba Mercy, Kachele Annie, Chalubemba Yahns, Toloka Paul, Hamooya Benson M
Pathology Laboratory Department, Research Section, Livingstone Central Hospital, Akapelwa Street, P.O. Box 60091, Livingstone, Zambia.
Department of Biomedical Sciences, School of Health Sciences, University of Zambia, P.O. Box 50110, Lusaka, Zambia.
BMC Res Notes. 2018 Oct 4;11(1):701. doi: 10.1186/s13104-018-3808-5.
To synthesize lessons from comparison of results obtained from the immuno-chromatographic SD Bioline testing method and the chemiluminescent micro-particle immunoassay Architect in the diagnosis of syphilis at Livingstone Central hospital laboratory.
The specificity and sensitivity of SD Bioline syphilis 3.0 against the chemiluminescent immunoassay using the Architect syphilis Treponema pallidum (TP) was 85.3% and 91.3% respectively with substantial agreement between the two test methods (88%, ĸ = 0.76; p < 0.0005). We recommend further comprehensive study with a larger sample size and clinical details to ascertain the validity of our findings. We also recommend using a non-treponemal test with the current treponemal tests being used to aid diagnosis.
综合分析利文斯通中央医院实验室采用免疫层析法SD Bioline检测方法与化学发光微粒子免疫分析法Architect在梅毒诊断中的结果比较。
SD Bioline梅毒3.0检测法相对于使用Architect梅毒螺旋体（TP）化学发光免疫分析法的特异性和敏感性分别为85.3%和91.3%，两种检测方法之间具有高度一致性（88%，ĸ = 0.76；p < 0.0005）。我们建议开展进一步的综合研究，扩大样本量并提供临床细节，以确定我们研究结果的有效性。我们还建议在当前使用的梅毒螺旋体检测方法基础上，结合非梅毒螺旋体检测方法辅助诊断。
