Rachdi Chaima, Damak Rahma, Fekih Romdhane Feten, Ouertani Haroun, Cheour Majda
Ibn Oumrane Psychiatry Department, Razi Hospital, Manouba, Tunisia; Faculty of Medecine, Tunis El Manar University, Tunisia.
Ibn Oumrane Psychiatry Department, Razi Hospital, Manouba, Tunisia; Faculty of Medecine, Tunis El Manar University, Tunisia.
Prim Care Diabetes. 2019 Feb;13(1):57-62. doi: 10.1016/j.pcd.2018.09.003. Epub 2018 Oct 2.
Depression is prevalent in patients with type 2 diabetes. It may have a negative impact on the management of diabetes mellitus and could affect weight. The main aim of the investigation was to evaluate the effect of antidepressant treatment (sertraline) on anthropometric variables and glycemic control in depressed type 2 diabetic patients.
Thirty three type 2 diabetic outpatients depressed received open-label sertraline therapy for up to 12 weeks. Clinical outcome measures included the 17-item Hamilton depression rating. Changes in the anthropometrics variables were evaluated by measuring weight, waist circumference and by calculating body mass index at three, six and 12 weeks of treatment. In addition, fasting, postprandial plasma glucose level, glycosylated hemoglobin-A 1C measures, lipid and renal profile were obtained before and during sertraline therapy.
Weight decreased significantly (-2kg; p=0.000) and body mass index decreased from 30.41kg/m to 29.6kg/m (p=0.000). Patients lost on average seven centimeters in waist circumference (p=0.000). We also observed a modest, non-significant reduction in fasting, postprandial and glycosylated hemoglobin. We observed a significant reduction in mean score according to the Hamilton depression scale (p=0.000) CONCLUSION: Our study results suggested that sertraline produced a benefic effect on weight, body mass index and waist circumference at 12-week follow up.
抑郁症在2型糖尿病患者中普遍存在。它可能对糖尿病的管理产生负面影响，并可能影响体重。本研究的主要目的是评估抗抑郁治疗（舍曲林）对抑郁的2型糖尿病患者人体测量学变量和血糖控制的影响。
33名抑郁的2型糖尿病门诊患者接受了为期12周的开放标签舍曲林治疗。临床结局指标包括17项汉密尔顿抑郁量表评分。通过在治疗的3周、6周和12周测量体重、腰围并计算体重指数来评估人体测量学变量的变化。此外，在舍曲林治疗前和治疗期间获取空腹、餐后血糖水平、糖化血红蛋白A1C测量值、血脂和肾功能指标。
体重显著下降（-2kg；p=0.000），体重指数从30.41kg/m降至29.6kg/m（p=0.000）。患者腰围平均减少了7厘米（p=0.000）。我们还观察到空腹、餐后血糖和糖化血红蛋白有适度的、不显著的降低。根据汉密尔顿抑郁量表，我们观察到平均评分显著降低（p=0.000）。结论：我们的研究结果表明，在12周的随访中，舍曲林对体重、体重指数和腰围产生了有益影响。
