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继发于达比加群的自发性脾破裂:一连串不幸事件中的最后一件。

Spontaneous splenic rupture secondary to dabigatran: the last in a series of unfortunate events.

机构信息

Royal Berkshire Hospital, Reading, UK

Royal Berkshire Hospital, Reading, UK.

出版信息

Clin Med (Lond). 2018 Oct;18(5):406-408. doi: 10.7861/clinmedicine.18-5-406.

DOI:10.7861/clinmedicine.18-5-406
PMID:30287437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6334098/
Abstract

We present the case of a 77-year-old woman who had an accidental fall in her garden, resulting in a fracture of her left ankle. After manipulation of the fracture, she developed sudden onset shortness of breath. An echo led to the diagnosis of Takotsubo cardiomyopathy. Shortly after this she developed sudden onset receptive and expressive dysphasia. Magnetic resonance imaging (MRI) of the head confirmed a left parietal infarct thought to be secondary to left ventricular thrombus formation. She was started on dabigatran. A few days later, she developed abdominal pain, and was subsequently diagnosed with a spontaneous splenic rupture. This case was interesting due to the unusual chain of events following a simple fall, and also a rare complication of anticoagulant therapy.

摘要

我们报告了一例 77 岁女性,她在花园里意外摔倒,导致左踝关节骨折。骨折复位后,她突然出现呼吸急促。超声心动图诊断为应激性心肌病。此后不久,她突然出现接受性和表达性语言障碍。头部磁共振成像(MRI)证实左侧顶叶梗死,考虑继发于左心室血栓形成。她开始接受达比加群治疗。几天后,她出现腹痛,随后被诊断为自发性脾破裂。本例病例很有趣,因为这是一个简单跌倒后发生的不常见的连锁事件,也是抗凝治疗的罕见并发症。

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引用本文的文献

1
Splenic rupture.脾破裂
Clin Med (Lond). 2019 Mar;19(2):188-189. doi: 10.7861/clinmedicine.19-2-188.
2
Atraumatic splenic rupture associated with apixaban.与阿哌沙班相关的非创伤性脾破裂。
SAGE Open Med Case Rep. 2019 Feb 21;7:2050313X19832490. doi: 10.1177/2050313X19832490. eCollection 2019.

本文引用的文献

1
Stress-induced thrombus: prevalence of thromboembolic events and the role of anticoagulation in Takotsubo cardiomyopathy.应激性血栓形成:Takotsubo心肌病中血栓栓塞事件的发生率及抗凝治疗的作用
Ann Transl Med. 2018 Jan;6(1):4. doi: 10.21037/atm.2017.11.01.
2
Left Ventricular Thrombi in Takotsubo Syndrome: Incidence, Predictors, and Management: Results From the GEIST (German Italian Stress Cardiomyopathy) Registry.Takotsubo 综合征中的左心室血栓:发生率、预测因素和管理:来自 GEIST(德意应激性心肌病)注册研究的结果。
J Am Heart Assoc. 2017 Dec 4;6(12):e006990. doi: 10.1161/JAHA.117.006990.
3
Spontaneous splenic rupture associated with apixaban: a case report.阿哌沙班相关的自发性脾破裂:一例报告
J Med Case Rep. 2016 Aug 9;10(1):217. doi: 10.1186/s13256-016-1012-6.
4
Non-traumatic splenic rupture in a patient on oral anticoagulation.口服抗凝治疗患者的非创伤性脾破裂
Int J Emerg Med. 2013 May 21;6(1):16. doi: 10.1186/1865-1380-6-16.
5
Systematic review of atraumatic splenic rupture.非创伤性脾破裂的系统评价
Br J Surg. 2009 Oct;96(10):1114-21. doi: 10.1002/bjs.6737.