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Circulation. 2018 Mar 6;137(10):1039-1048. doi: 10.1161/CIRCULATIONAHA.117.031841. Epub 2017 Nov 11.
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Alterations in Cardiac Deformation, Timing of Contraction and Relaxation, and Early Myocardial Fibrosis Accompany the Apparent Recovery of Acute Stress-Induced (Takotsubo) Cardiomyopathy: An End to the Concept of Transience.心肌变形、收缩和舒张时间的改变以及早期心肌纤维化伴随着急性应激诱导（心尖球囊样综合征）心肌病的明显恢复：短暂性概念的终结。
J Am Soc Echocardiogr. 2017 Aug;30(8):745-755. doi: 10.1016/j.echo.2017.03.016. Epub 2017 Jun 7.
3
Electrophysiological effects of anthracyclines in adult survivors of pediatric malignancy.蒽环类药物对儿童恶性肿瘤成年幸存者的电生理影响。
Pediatr Blood Cancer. 2017 Nov;64(11). doi: 10.1002/pbc.26556. Epub 2017 Apr 28.
4
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Cardiovasc Drugs Ther. 2017 Feb;31(1):63-75. doi: 10.1007/s10557-016-6711-0.
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Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline.成人癌症幸存者心功能障碍的预防和监测：美国临床肿瘤学会临床实践指南。
J Clin Oncol. 2017 Mar 10;35(8):893-911. doi: 10.1200/JCO.2016.70.5400. Epub 2016 Dec 5.
6
Functional recovery of regional myocardial deformation in patients with takotsubo cardiomyopathy.应激性心肌病患者局部心肌变形的功能恢复
J Cardiol. 2017 Jul;70(1):68-73. doi: 10.1016/j.jjcc.2016.09.006. Epub 2016 Nov 23.
7
Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology.Takotsubo 综合征的现有知识状况：欧洲心脏病学会心力衰竭协会 Takotsubo 综合征工作组的立场声明。
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Relation of delayed recovery of myocardial function after takotsubo cardiomyopathy to subsequent quality of life.应激性心肌病后心肌功能延迟恢复与后续生活质量的关系。
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关键问题：一名接受蒽环类药物治疗的肿瘤患者出现反向应激性心肌病。

Heart of the matter: reverse takotsubo syndrome in an anthracycline-exposed oncology patient.

作者信息

Voit Jay, Tibrewala Anjan, Akhter Nausheen

机构信息

Department of Medicine, Northwestern Memorial Hospital, Chicago, Illinois, USA.

Department of Medicine, Division of Cardiology, Northwestern Memorial Hospital, Chicago, Illinois, USA.

出版信息

BMJ Case Rep. 2018 Oct 3;2018:bcr-2018-226378. doi: 10.1136/bcr-2018-226378.

DOI:10.1136/bcr-2018-226378
PMID:30287630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6194443/
Abstract

A 24-year-old man with acute myelogenous leukaemia and a history of anthracycline treatment is hospitalised for non-anthracycline chemotherapy. He develops new-onset heart failure requiring intesive care unit (ICU) admission during his stay. There is debate as to the aetiology of his heart failure, whether anthracycline cardiotoxicity or takotsubo syndrome. He is diuresed and discharged home with close follow-up. Ultimately, the retrospective use of two-dimensional speckle-tracking echocardiography derived strain helps diagnose reverse takotsubo syndrome.

摘要

一名24岁患有急性髓性白血病且有蒽环类药物治疗史的男性因接受非蒽环类化疗而住院。住院期间，他出现了新发心力衰竭，需要入住重症监护病房（ICU）。关于其心力衰竭的病因存在争议，是蒽环类药物心脏毒性还是应激性心肌病。他接受了利尿治疗并出院，进行密切随访。最终，回顾性应用二维斑点追踪超声心动图衍生应变有助于诊断反向应激性心肌病。