E-钙黏蛋白在口腔鳞状细胞癌进展中的作用：一项回顾性免疫组织化学研究
Role of E-cadherin in Progression of Oral Squamous Cell Carcinoma: A Retrospective Immunohistochemical Study.
作者信息
Gupta Awadhesh, Sharma Seema, Batra Monisha, Abidullah Mohammed, Bhuvinder Swathi, Katragadda Padmavathi
机构信息
Department of Oral and Maxillofacial Pathology, ESIC Dental College and Hospital, Rohini, New Delhi, India, Phone: +919711927559, e-mail:
Department of Oral and Maxillofacial Pathology and Microbiology, Santosh Dental College and Hospital, Ghaziabad Uttar Pradesh, India.
出版信息
J Contemp Dent Pract. 2018 Sep 1;19(9):1105-1110.
AIM
The aim of present study was to assess the role of E-cadherin in oral carcinogenesis by comparing their expressions in normal oral mucosa, oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC).
MATERIALS AND METHODS
To elucidate the pattern of E-cadherin expression in oral carcinogenesis, 21 archival cases of formalin-fixed paraffin-embedded sections of OSCC, 21 OED, and 7 normal oral mucosa samples as control were used for the study.
RESULTS
We observed reduction/loss of E-cadherin in membranous expression pattern and staining intensity with progression from dysplasia to oral cancer.
CONCLUSION
A decrease in staining intensity and loss of E-cadherin membranous expression were noted from dysplasia to carcinoma, suggesting its role as a tumor suppressor gene.
CLINICAL SIGNIFICANCE
E-cadherin can be used as a biomarker to assess and evaluate the progression and prognosis of oral dysplastic lesions and OSCC.
目的
本研究旨在通过比较E-钙黏蛋白在正常口腔黏膜、口腔上皮发育异常（OED）和口腔鳞状细胞癌（OSCC）中的表达，评估其在口腔癌发生中的作用。
材料与方法
为阐明E-钙黏蛋白在口腔癌发生中的表达模式，本研究使用了21例经福尔马林固定、石蜡包埋的OSCC切片存档病例、21例OED病例以及7例正常口腔黏膜样本作为对照。
结果
我们观察到，随着发育异常进展为口腔癌，E-钙黏蛋白的膜表达模式和染色强度降低/丧失。
结论
从发育异常到癌症，E-钙黏蛋白的染色强度降低且膜表达丧失，提示其作为肿瘤抑制基因的作用。
临床意义
E-钙黏蛋白可作为一种生物标志物，用于评估和评价口腔发育异常病变和OSCC的进展及预后。
Zotero 插件